The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-kappa B-related signaling pathways
文献类型：期刊论文
| 作者 | Zhou, HJ; Zhao, K; 李炜(多); 陈春英;Li, W; Yang, N; Liu, Y; Chen, CY; Wei, TT |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:29页码:6933-6942 |
| 关键词 | Graphene Macrophage Cytokines Chemokines NF-kappa B Innate immune system |
| 英文摘要 | Graphene may have attractive properties for some biomedical applications, but its potential adverse biological effects, in particular, possible modulation of immune responses, require further investigation. Macrophages are one of the most important effector cells of the innate immune system, and play pivotal roles in the response to graphene exposure. We have previously reported that exposure of macrophages to high concentrations of graphene triggers cell death via MAPK- and TGF-related pathways. However, little is known about the influence of exposure to low concentrations of graphene on the function of macrophages. In the present investigation, we demonstrate the biological effects of sub-cytotoxic concentrations of commercial pristine graphene on both primary murine macrophages and immortalized macrophages. Graphene significantly stimulates the secretion of Th1/Th2 cytokines including IL-1 alpha, IL-6, IL-10, TNF-alpha and GM-CSF as well as chemokines such as MCP-1, MIP-1 alpha, MIP-1 beta and RANTES, probably by activating TLR-mediated and NF-kappa B-dependent transcription. Furthermore, these graphene-induced factors alter the morphology of naive macrophages by remodeling their actin assembly, decreasing their ability to adhere to the extracellular matrix, and attenuating their phagocytosis. This negative feedback of the immune response of macrophages by graphene-induced factors may play an important role in the prevention of their over-activation after graphene exposure. These findings shed light on the interaction of graphene and macrophages in vitro. Further research is needed to systematically assess the biological responses of graphene, both to improve its safety and to contribute to the design of new biological applications. (C) 2012 Elsevier Ltd. All rights reserved. |
| 学科主题 | Engineering; Materials Science |
| 收录类别 | SCI |
| WOS记录号 | WOS:000308269600004 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224285]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhou, HJ,Zhao, K,Li W,et al. The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-kappa B-related signaling pathways[J]. BIOMATERIALS,2012,33(29):6933-6942. |
| APA | Zhou, HJ.,Zhao, K.,李炜.,陈春英；Li, W.,Yang, N.,...&Wei, TT.(2012).The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-kappa B-related signaling pathways.BIOMATERIALS,33(29),6933-6942. |
| MLA | Zhou, HJ,et al."The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-kappa B-related signaling pathways".BIOMATERIALS 33.29(2012):6933-6942. |
入库方式： OAI收割
来源：高能物理研究所
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