Impacts of fullerene derivatives on regulating the structure and assembly of collagen molecules
文献类型：期刊论文
| 作者 | Yin XH(尹晓慧); Zhao LN(赵丽娜) ; Yin, XH; Zhao, LN; Kang, SG; Pan, J; Song, Y; Zhang, MY; Xing, GM; Wang, F
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| 刊名 | NANOSCALE
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:16页码:7341-7348 |
| 英文摘要 | During cancer development, the fibrous layers surrounding the tumor surface get thin and stiff which facilitates the tumor metastasis. After the treatment of metallofullerene derivatives Gd@C-82(OH)(22), the fibrous layers become thicker and softer, the metastasis of tumor is then largely suppressed. The effect of Gd@C-82(OH)(22) was found to be related to their direct interaction with collagen and the resulting impact on the structure of collagen fibrils, the major component of extracellular matrices. In this work we study the interaction of Gd@C-82(OH)(22) with collagen by molecular dynamics simulations. We find that Gd@C-82(OH)(22) can enhance the rigidity of the native structure of collagen molecules and promote the formation of an oligomer or a microfibril. The interaction with Gd@C-82(OH)(22) may regulate further the assembly of collagen fibrils and change the biophysical properties of collagen. The control run with fullerene derivatives C-60(OH)(24) also indicates that C-60(OH)(24) can influence the structure and assembly of collagen molecules as well, but to a lesser degree. Both fullerene derivatives can form hydrogen bonds with multiple collagen molecules acting as a "fullerenol-mediated bridge" that enhance the interaction within or among collagen molecules. Compared to C-60(OH)(24), the interaction of Gd@C-82(OH)(22) with collagen is stronger, resulting in particular biomedical effects for regulating the biophysical properties of collagen fibrils. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000322315600031 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224296]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Yin XH,Zhao LN,Yin, XH,et al. Impacts of fullerene derivatives on regulating the structure and assembly of collagen molecules[J]. NANOSCALE,2013,5(16):7341-7348. |
| APA | 尹晓慧.,赵丽娜.,Yin, XH.,Zhao, LN.,Kang, SG.,...&赵宇亮.(2013).Impacts of fullerene derivatives on regulating the structure and assembly of collagen molecules.NANOSCALE,5(16),7341-7348. |
| MLA | 尹晓慧,et al."Impacts of fullerene derivatives on regulating the structure and assembly of collagen molecules".NANOSCALE 5.16(2013):7341-7348. |
入库方式： OAI收割
来源：高能物理研究所
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