A new near infrared photosensitizing nanoplatform containing blue-emitting up-conversion nanoparticles and hypocrellin A for photodynamic therapy of cancer cells
文献类型：期刊论文
| 作者 | Jin S(金珊); Zhou LJ(周良军); Gu ZJ(谷战军) ; Jin, S; Zhou, LJ; Gu, ZJ; Tian, G; Yan, L; Ren, WL; Yin, WY
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| 刊名 | NANOSCALE
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:23页码:11910-11918 |
| 英文摘要 | The utilization of up-conversion nanoparticles (UCNPs) for photodynamic therapy (PDT) has gained significant interest due to their unique ability to convert near infrared light to UV/visible light. Previous work mainly focused on the fabrication of green and red emitting UCNPs to load photosensitizers (PSs) for PDT. In this work, we firstly developed a new multifunctional nanoplatform combining blue-emitting UCNPs with blue-light excited PS (hypocrellin A, HA) as a NIR photosensitizing nanoplatform for PDT of cancer cells. Tween 20 coated NaYbF4:Tm, Gd@NaGdF4 UCNPs (Tween 20-UCNPs) with strong blue up-conversion luminescence and good water dispersibility were prepared for use as PS carriers. The blue emission band matched well with the efficient absorption band of HA, thereby facilitating the resonance energy transfer from UCNPs to HA and then activating HA to produce singlet oxygen (O-1(2)). The in vitro study showed that these Tween 20-UCNPs@HA complexes could efficiently produce O-1(2) to kill cancer cells under 980 nm NIR excitation. Moreover, these Gd3+ and Yb3+ containing nanoparticles also exhibited positive contrast effects in both T-1 weighted magnetic resonance imaging (MRI) and computed tomography (CT) imaging, making them become a multifunctional platform for simultaneous PDT and bio-imaging. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000326982000070 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224337]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Jin S,Zhou LJ,Gu ZJ,et al. A new near infrared photosensitizing nanoplatform containing blue-emitting up-conversion nanoparticles and hypocrellin A for photodynamic therapy of cancer cells[J]. NANOSCALE,2013,5(23):11910-11918. |
| APA | 金珊.,周良军.,谷战军.,Jin, S.,Zhou, LJ.,...&赵宇亮.(2013).A new near infrared photosensitizing nanoplatform containing blue-emitting up-conversion nanoparticles and hypocrellin A for photodynamic therapy of cancer cells.NANOSCALE,5(23),11910-11918. |
| MLA | 金珊,et al."A new near infrared photosensitizing nanoplatform containing blue-emitting up-conversion nanoparticles and hypocrellin A for photodynamic therapy of cancer cells".NANOSCALE 5.23(2013):11910-11918. |
入库方式： OAI收割
来源：高能物理研究所
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