Water-miscible organic J-aggregate nanoparticles as efficient two-photon fluorescent nano-probes for bio-imaging
文献类型：期刊论文
| 作者 | Xu, ZZ; Liao, Q; Wu, YS; Ren, WL; Li, W; Liu, LB; Wang, S; Gu, ZJ; Zhang, HL; Fu, HB;任文璐 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY
 |
| 出版日期 | 2012 |
| 卷号 | 22期号:34页码:17737-17743 |
| 英文摘要 | Many two-photon absorption (TPA) organic dyes are water insoluble and suffer from strong fluorescence quenching in aqueous media due to the self-aggregation effect. This seriously limits their applications as two-photon fluorescence (TPF) probes in bio-imaging. By employing a reprecipitation method, we prepared ultrabright water-miscible organic nanoparticles (ONPs) of 1,4-dimethoxy-2,5-di[4'-(cyano)styryl]benzene (COPV). The single-crystal structure reveals that the cooperation between pi-pi stacking and hydrogen-bonding interactions drives COPV molecules into a brickwork arrangement of J-aggregates, in which the coherent excitation delocalization reaches 2-3 molecules. Due to the superradiance of J-aggregates, COPV ONPs are highly emissive in aqueous media with a quantum yield >0.4; meanwhile, their TPA cross-section is greatly enhanced, probably due to exciton-vibration coupling. As TPF probes, COPV J-aggregate ONPs are 3-4 orders of magnitude brighter than conventional fluorescent dyes and an order of magnitude brighter than quantum dots. Moreover, these ONPs exhibit no obvious cytotoxicity at concentrations as high as 100 mu g mL(-1). Our results demonstrate that ultrabright J-aggregate ONPs of COPV provide a new strategy to construct efficient TPF nano-probes for bio-imaging. |
| 学科主题 | Chemistry; Materials Science |
| 收录类别 | SCI |
| WOS记录号 | WOS:000307305700050 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224357]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Xu, ZZ,Liao, Q,Wu, YS,et al. Water-miscible organic J-aggregate nanoparticles as efficient two-photon fluorescent nano-probes for bio-imaging[J]. JOURNAL OF MATERIALS CHEMISTRY,2012,22(34):17737-17743. |
| APA | Xu, ZZ.,Liao, Q.,Wu, YS.,Ren, WL.,Li, W.,...&谷战军.(2012).Water-miscible organic J-aggregate nanoparticles as efficient two-photon fluorescent nano-probes for bio-imaging.JOURNAL OF MATERIALS CHEMISTRY,22(34),17737-17743. |
| MLA | Xu, ZZ,et al."Water-miscible organic J-aggregate nanoparticles as efficient two-photon fluorescent nano-probes for bio-imaging".JOURNAL OF MATERIALS CHEMISTRY 22.34(2012):17737-17743. |
入库方式： OAI收割
来源：高能物理研究所
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