Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy
文献类型：期刊论文
| 作者 | Yang, H; Sun, CJ; Fan, ZL; Tian, X; Yan, L; Du, LB; Liu, Y; Chen, CY; Liang, XJ; Anderson, GJ |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2012 |
| 卷号 | 2页码:847 |
| 英文摘要 | Nanoparticle exposure in pregnancy may result in placental damage and fetotoxicity; however, the factors that determine fetal nanoparticle exposure are unclear. Here we have assessed the effect of gestational age and nanoparticle composition on fetal accumulation of maternally-administered nanomaterials in mice. We determined the placental and fetal uptake of 13 nm gold nanoparticles with different surface modifications (ferritin, PEG and citrate) following intravenous administration at E5.5-15.5. We showed that prior to E11.5, all tested nanoparticles could be visualized and detected in fetal tissues in significant amounts; however, fetal gold levels declined dramatically post-E11.5. In contrast, Au-nanoparticle accumulation in the extraembryonic tissues (EET) increased 6-15 fold with gestational age. Fetal and EET accumulation of ferritin-and PEG-modified nanoparticles was considerably greater than citrate-capped nanoparticles. No signs of toxicity were observed. Fetal exposure to nanoparticles in murine pregnancy is, therefore, influenced by both stage of embryonic/placental maturation and nanoparticle surface composition. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000311100600001 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224442]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Yang, H,Sun, CJ,Fan, ZL,et al. Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy[J]. SCIENTIFIC REPORTS,2012,2:847. |
| APA | Yang, H.,Sun, CJ.,Fan, ZL.,Tian, X.,Yan, L.,...&赵宇亮.(2012).Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy.SCIENTIFIC REPORTS,2,847. |
| MLA | Yang, H,et al."Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy".SCIENTIFIC REPORTS 2(2012):847. |
入库方式： OAI收割
来源：高能物理研究所
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