Ultrabright and Multicolorful Fluorescence of Amphiphilic Polyethyleneimine Polymer Dots for Efficiently Combined Imaging and Therapy
文献类型：期刊论文
| 作者 | Sun, Y; Cao, WP; Li, SL; Jin, SB; Hu, KL; Hu, LM; Huang, YY; Gao, XY; Wu, Y; Liang, XJ;高学云 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2013 |
| 卷号 | 3页码:3036 |
| 英文摘要 | Multifunctional nanoparticles as theranostic tools hold great potential for its unique and efficient way to visualize the process of disease treatment. However, the toxicity of conventional fluorescent labels and difficulty of functionalization limit their widespread use. Recently, a number of amino-rich polymers have demonstrated high luminescent fluorescence but rarely showed potential for in vivo imaging due to their blue fluorescence. Here, a general route has been found to construct polymer-based multifunctional nanoparticles for combined imaging and drug delivering. The weak fluorescent polyethyleneimine (PEI) has been conjugated with hydrophobic polylactide as the amphiphilic PEI for construction of nanoparticles which showed bright and multicolor fluorescence with high drug loading capacity. The paclitaxel-loaded nanoparticles showed significant therapy effect in contrast to the free paclitaxel. Meanwhile, fluorescence imaging of the nanoparticles showed accumulation around tumor. These results demonstrate a new type of polymer-based multifunctional nanoparticles for imaging-guided drug delivery. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000326031200001 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224469]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Sun, Y,Cao, WP,Li, SL,et al. Ultrabright and Multicolorful Fluorescence of Amphiphilic Polyethyleneimine Polymer Dots for Efficiently Combined Imaging and Therapy[J]. SCIENTIFIC REPORTS,2013,3:3036. |
| APA | Sun, Y.,Cao, WP.,Li, SL.,Jin, SB.,Hu, KL.,...&Liang, XJ；高学云.(2013).Ultrabright and Multicolorful Fluorescence of Amphiphilic Polyethyleneimine Polymer Dots for Efficiently Combined Imaging and Therapy.SCIENTIFIC REPORTS,3,3036. |
| MLA | Sun, Y,et al."Ultrabright and Multicolorful Fluorescence of Amphiphilic Polyethyleneimine Polymer Dots for Efficiently Combined Imaging and Therapy".SCIENTIFIC REPORTS 3(2013):3036. |
入库方式： OAI收割
来源：高能物理研究所
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