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High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy
文献类型：期刊论文
| 作者 | Yin WY(尹文艳) ; Yan L(晏亮); Yu J(余杰); Yin, WY; Yan, L; Yu, J; Tian, G; Zhou, LJ; Zheng, XP; Zhang, X
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| 刊名 | ACS NANO
 |
| 出版日期 | 2014 |
| 卷号 | 8期号:7页码:6922-6933 |
| 关键词 | single-layer MoS2 nanosheets high-throughput oleum treatment exfoliation strategy NIR-triggered drug delivery |
| 英文摘要 | We report here a simple, high-yield yet low-cost approach to design single-layer MoS2 nanosheets with controllable size via an improved oleum treatment exfoliation process. By decorating MoS2 nanosheets with chitosan, these functionalized MoS2 nanosheets have been developed as a chemotherapeutic drug nanocarrier for near-infrared (NIR) photothermal-triggered drug delivery, facilitating the combination of chemotherapy and photothermal therapy into one system for cancer therapy. Loaded doxorubicin could be controllably released upon the photothermal effect induced by 808 nm NIR laser irradiation. In vitro and in vivo tumor ablation studies demonstrate a better synergistic therapeutic effect of the combined treatment, compared with either chemotherapy or photothermal therapy alone. Finally, MoS2 nanosheets can also be used as a promising contrast agent in X-ray computed tomography imaging due to the obvious X-ray absorption ability of Mo. As a result, the high-throughput oleum treatment exfoliation process could be extended for fabricating other 2D nanomaterials, and the NIR-triggered drug release strategy was encouraging for simultaneous imaging-guided cancer theranostic application. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science |
| 收录类别 | SCI |
| WOS记录号 | WOS:000339463100047 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224786]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Yin WY,Yan L,Yu J,et al. High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy[J]. ACS NANO,2014,8(7):6922-6933. |
| APA | 尹文艳.,晏亮.,余杰.,Yin, WY.,Yan, L.,...&赵宇亮.(2014).High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy.ACS NANO,8(7),6922-6933. |
| MLA | 尹文艳,et al."High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy".ACS NANO 8.7(2014):6922-6933. |
入库方式： OAI收割
来源：高能物理研究所
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