Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapy in Vitro
文献类型：期刊论文
| 作者 | Gao J(高靓) ; Liu R(刘茹); Gao FP(高福平); Gao, H; Liu, R; Gao, FP; Wang, YL; Jiang, XL; Gao, XY;; Wang YL(王亚玲)
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| 刊名 | ACS NANO
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| 出版日期 | 2014 |
| 卷号 | 8期号:7页码:7260-7271 |
| 关键词 | gold nanocages reactive oxygen species photodynamic therapy plasmon-enabled photochemistry hot electrons two-photon |
| 英文摘要 | We have performed fundamental assays of gold nanocages (AuNCs) as intrinsic inorganic photosensitizers mediating generation of reactive oxygen species (ROS) by plasmon-enabled photochemistry under near-infrared (NIR) one/two-photon irradiation. We disclosed that NIR light excited hot electrons transform into either ROS or hyperthermia. Electron spin resonance spectroscopy was applied to demonstrate the production of three main radical species, namely, singlet oxygen (O-1(2)), superoxide radical anion (O-2(-center dot)), and hydroxyl radical ((OH)-O-center dot). The existence of hot electrons from irradiated AuNCs was confirmed by a well-designed photoelectrochemical experiment based on a three-electrode system. It could be speculated that surface plasmons excited in AuNCs first decay into hot electrons, and then the generated hot electrons sensitize oxygen to form ROS through energy and electron transfer modes. We also compared AuNCs' ROS generation efficiency in different surface chemical environments under one/two-photon irradiation and verified that, compared with one-photon irradiation, two-photon irradiation could bring about much more ROS. furthermore, in vitro, under two-photon irradiation, ROS can trigger mitochondrial depolarization and caspase protein up-regulation to initiate tumor cell apoptosis. Meanwhile, hyperthermia mainly induces tumor cell necrosis. Our findings suggest that plasmon-mediated ROS and hyperthermia can be facilely regulated for optimized anticancer phototherapy. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science |
| 收录类别 | SCI |
| WOS记录号 | WOS:000339463100083 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224787]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Gao J,Liu R,Gao FP,et al. Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapy in Vitro[J]. ACS NANO,2014,8(7):7260-7271. |
| APA | 高靓.,刘茹.,高福平.,Gao, H.,Liu, R.,...&高学云.(2014).Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapy in Vitro.ACS NANO,8(7),7260-7271. |
| MLA | 高靓,et al."Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapy in Vitro".ACS NANO 8.7(2014):7260-7271. |
入库方式： OAI收割
来源：高能物理研究所
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