The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration
文献类型：期刊论文
| 作者 | Zhou, HJ; Zhang, B; Zheng JJ(郑佳佳); Zheng, JJ; Yu, MF; Zhou, T; Zhao, K; Jia, YX; Gao, XF; Chen, CY |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:5页码:1597-1607 |
| 关键词 | Graphene Cancer cell Metastasis Mitochondria Electron transfer chain Iron-sulfur center |
| 英文摘要 | Graphene and its derivatives have become important nanomaterials worldwide and have potential medical applications including in vivo diagnosis, drug delivery, and photothermal therapy of cancer. However, little is known about their effect on the metastasis of cancer cells, which is the cause of over 90% of patient deaths. In the present investigation, we provide direct evidence that low concentrations of pristine graphene and graphene oxide show no apparent influence on the viability of MDA-MB-231 human breast cancer cells, PC3 human prostate cancer cells, as well as Bl6F10 mouse melanoma cells. However, both pristine graphene and graphene oxide can effectively inhibit the migration and invasion of these cancer cells. Further studies indicate that exposure of cells to graphene led to the direct inhibition of the electron transfer chain complexes I, II, III and IV, most likely by disrupting electron transfer between iron-sulfur centers, which is due to its stronger ability to accept electrons compared to ironsulfur clusters through theoretical calculations. The decreased electron transfer chain activity caused a reduction in the production of ATP and subsequent impairment of F-actin cytoskeleton assembly, which is crucial for the migration and invasion of metastatic cancer cells. The inhibition of cancer cell metastasis by graphene and graphene oxide might provide new insights into specific cancer treatment. (C) 2013 Elsevier Ltd. All rights reserved. |
| 学科主题 | Engineering; Materials Science |
| 收录类别 | SCI |
| WOS记录号 | WOS:000330156100024 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224859]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhou, HJ,Zhang, B,Zheng JJ,et al. The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration[J]. BIOMATERIALS,2014,35(5):1597-1607. |
| APA | Zhou, HJ.,Zhang, B.,郑佳佳.,Zheng, JJ.,Yu, MF.,...&陈春英.(2014).The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration.BIOMATERIALS,35(5),1597-1607. |
| MLA | Zhou, HJ,et al."The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration".BIOMATERIALS 35.5(2014):1597-1607. |
入库方式： OAI收割
来源：高能物理研究所
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