Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles
文献类型：期刊论文
| 作者 | Gao FP(高福平) ; Yuan Q(袁卿); Gao J(高靓); Gao, FP; Yuan, Q; Gao, L; Cai, PJ; Zhu, HR; Liu, R; Wang, YL
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| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:31页码:8854-8866 |
| 关键词 | Selenium nanoparticle Toxicity Antitumor drug Apoptosis Nrf2-ARE pathway |
| 英文摘要 | Although chemotherapeutic drugs are widely applied for clinic tumor treatment, severe toxicity restricts their therapeutic efficacy. In this study, we reported a new form of selenium, selenium nanoparticles (Nano Se) which have significant lower toxicity and acceptable bioavailability. We investigated Nano Se as chemotherapy preventive agent to protect against toxicities of anticancer drug irinotecan and synergistically enhance the anti-tumor treatment effect in vitro and in vivo. The underlying mechanisms were also investigated. The combination of Nano Se and irinotecan showed increased cytotoxic effect with HCT-8 tumor cells likely by p53 mediated apoptosis. Nano Se inhibited growth of HCT-8 tumor cells partially through caspases mediated apoptosis. In vivo experiment showed Nano Se at a dose of 4 mg/kg/day significantly alleviated adverse effects induced by irinotecan (60 mg/kg) treatment. Nano Se alone treatment did not induce any toxic manifestations. The combination of Nano Se and irinotecan dramatically inhibited tumor growth and significantly induced apoptosis of tumor cells in HCT-8 cells xenografted tumor. Tumor inhibition rate was about 17.2%, 48.6% and 62.1% for Nano Se, irinotecan and the combination of Nano Se and irinotecan, respectively. The beneficial effects of Nano Se for tumor therapy were mainly ascribed to selectively regulating Nrf2-ARE (antioxidant responsive elements) pathway in tumor tissues and normal tissues. Our results suggest Nano Se is a promising selenium species with potential application in cancer treatment. (C) 2014 Elsevier Ltd. All rights reserved. |
| 学科主题 | Engineering; Materials Science |
| 收录类别 | SCI |
| WOS记录号 | WOS:000340984600011 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224862]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Gao FP,Yuan Q,Gao J,et al. Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles[J]. BIOMATERIALS,2014,35(31):8854-8866. |
| APA | 高福平.,袁卿.,高靓.,Gao, FP.,Yuan, Q.,...&高学云.(2014).Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles.BIOMATERIALS,35(31),8854-8866. |
| MLA | 高福平,et al."Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles".BIOMATERIALS 35.31(2014):8854-8866. |
入库方式： OAI收割
来源：高能物理研究所
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