On-demand generation of singlet oxygen from a smart graphene complex for the photodynamic treatment of cancer cells
文献类型：期刊论文
| 作者 | Yan L(晏亮) ; Chang YN(常亚男); Yin WY(尹文燕); Yan, L; Chang, YN; Yin, WY; Tian, G; Zhou, LJ; Liu, XD; Xing, GM
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| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2014 |
| 卷号 | 2期号:10页码:1412-1418 |
| 英文摘要 | Graphene oxide (GO) has been proven to be a highly efficient long-range quencher for various fluorescence processes, which intrinsically work through a photophysical mechanism similar to that of singlet oxygen generation (SOG). Under our hypothesis that GO may be capable of quenching the SOG process, here we design and synthesize a novel nanocomplex consisting of GO, a photosensitizer and an aptamer. We demonstrate that GO is an ideal SOG controller, which can reversibly quench and recover SOG depending on the interaction intensity between GO and a photosensitizer. Additionally, it can simultaneously act as a carrier for the efficient loading and delivery of the photosensitizers to cancer cells. Thus, during the delivery process, SOG of the nanocomplex can be completely inhibited by the quenching capacity of the GO even though there is light present; however, when the nanocomplex enters into cancer cells where target molecules are present, SOG is triggered by a target binding event and singlet oxygen is reversibly released from the nanocomplex, ultimately inducing significant cell death in the presence of light. This proof-of-concept study provides a new chemical strategy for creating a highly selective photodynamic therapy with low toxicity, using hydrophilic GO-based systems. |
| 学科主题 | Materials Science |
| 收录类别 | SCI |
| WOS记录号 | WOS:000343034000011 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224864]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Yan L,Chang YN,Yin WY,et al. On-demand generation of singlet oxygen from a smart graphene complex for the photodynamic treatment of cancer cells[J]. BIOMATERIALS SCIENCE,2014,2(10):1412-1418. |
| APA | 晏亮.,常亚男.,尹文燕.,Yan, L.,Chang, YN.,...&赵宇亮.(2014).On-demand generation of singlet oxygen from a smart graphene complex for the photodynamic treatment of cancer cells.BIOMATERIALS SCIENCE,2(10),1412-1418. |
| MLA | 晏亮,et al."On-demand generation of singlet oxygen from a smart graphene complex for the photodynamic treatment of cancer cells".BIOMATERIALS SCIENCE 2.10(2014):1412-1418. |
入库方式： OAI收割
来源：高能物理研究所
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