Quantification of carbon nanomaterials in vivo: direct stable isotope labeling on the skeleton of fullerene C-60
文献类型：期刊论文
| 作者 | Chang XL(常雪灵) ; Ruan LF(阮龙飞); Yang ST(杨胜韬); Chang, XL; Ruan, LF; Yang, ST; Sun, BY; Guo, CB; Zhou, LJ; Dong, JQ
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| 刊名 | ENVIRONMENTAL SCIENCE-NANO
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| 出版日期 | 2014 |
| 卷号 | 1期号:1页码:64-70 |
| 英文摘要 | Concerns over the biosafety of carbon nanomaterials have been raised, due to their unique structure, properties and applications. However, a lack of easily accessible quantification methods for in vivo carbon nanomaterials largely limits the evaluation of their biosafety. Here, for the first time we adopted C-13 stable isotopic labeling for the quantification of a fullerene in vivo. C-13-enriched fullerene C-60 was synthesized by arc discharge and purified by high performance liquid chromatography. The C-13-enriched C-60 was dispersed in tween 80 aqueous solution for animal administration and was then monitored and quantified by isotope ratio mass spectrometry after intravenous injection (i.v.). Our results showed that C-60 quickly cleared from the blood circulation with a half-life of 14 min, and selective accumulation in the liver, spleen and lungs was observed, with slight decreases seen within 24 h. The pharmacokinetics of C-60 could be evaluated using the two-compartmental model, in which the fast clearance after i.v. from the blood circulation and slow clearance by the uptake in tissues were revealed. The present findings demonstrated the feasibility of using C-13 stable isotopically labeled carbon nanomaterials such as fullerene to trace and quantitatively monitor their bio-behavior in vivo, and suggested that C-13-enriched carbon nanomaterials might bring about a new platform to study the environmental fate of carbon nanomaterials. |
| 学科主题 | Chemistry; Environmental Sciences & Ecology; Science & Technology - Other Topics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000347971700007 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/225004]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Chang XL,Ruan LF,Yang ST,et al. Quantification of carbon nanomaterials in vivo: direct stable isotope labeling on the skeleton of fullerene C-60[J]. ENVIRONMENTAL SCIENCE-NANO,2014,1(1):64-70. |
| APA | 常雪灵.,阮龙飞.,杨胜韬.,Chang, XL.,Ruan, LF.,...&赵宇亮.(2014).Quantification of carbon nanomaterials in vivo: direct stable isotope labeling on the skeleton of fullerene C-60.ENVIRONMENTAL SCIENCE-NANO,1(1),64-70. |
| MLA | 常雪灵,et al."Quantification of carbon nanomaterials in vivo: direct stable isotope labeling on the skeleton of fullerene C-60".ENVIRONMENTAL SCIENCE-NANO 1.1(2014):64-70. |
入库方式： OAI收割
来源：高能物理研究所
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