Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein
文献类型：期刊论文
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| 作者 | Zhang JL(张九龙); Zhang, JL; Gao ZQ(高增强) ; Zhang, H; Gao, ZQ; Hu, HD; Dong, C; Dong, YH; Dong C(董城); Dong YH(董宇辉)
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| 刊名 | FEBS LETTERS
 ; FEBS LETTERS
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| 出版日期 | 2014 ; 2014 |
| 卷号 | 588期号:10页码:1891-1898 |
| 关键词 | The type VI secretion system VgrG3-TsaB complex Glycosyl hydrolase T4-lysozyme-like fold The type VI secretion system VgrG3-TsaB complex Glycosyl hydrolase T4-lysozyme-like fold |
| ISSN号 | 0014-5793 |
| DOI | 10.1016/j.febslet.2014.04.016 |
| 英文摘要 | The bacterial type VI secretion system (T6SS) is used by donor cells to inject toxic effectors into receptor cells. The donor cells produce the corresponding immunity proteins to protect themselves against the effector proteins, thereby preventing their self-intoxication. Recently, the C-terminal domain of VgrG3 was identified as a T6SS effector. Information on the molecular mechanism of VgrG3 and its immunity protein TsaB has been lacking. Here, we determined the crystal structures of native TsaB and the VgrG3C-TsaB complex. VgrG3C adopts a canonical phage-T4-lysozyme-like fold. TsaB interacts with VgrG3C through molecular mimicry, and inserts into the VgrG3C pocket.; The bacterial type VI secretion system (T6SS) is used by donor cells to inject toxic effectors into receptor cells. The donor cells produce the corresponding immunity proteins to protect themselves against the effector proteins, thereby preventing their self-intoxication. Recently, the C-terminal domain of VgrG3 was identified as a T6SS effector. Information on the molecular mechanism of VgrG3 and its immunity protein TsaB has been lacking. Here, we determined the crystal structures of native TsaB and the VgrG3C-TsaB complex. VgrG3C adopts a canonical phage-T4-lysozyme-like fold. TsaB interacts with VgrG3C through molecular mimicry, and inserts into the VgrG3C pocket. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics; Cell Biology ; Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| 收录类别 | SCI |
| 电子版国际标准刊号 | 1873-3468 |
| 语种 | 英语 |
| WOS记录号 | WOS:000336033700006 ; WOS:000336033700006 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/225013]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhang JL,Zhang, JL,Gao ZQ,et al. Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein, Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein[J]. FEBS LETTERS, FEBS LETTERS,2014, 2014,588, 588(10):1891-1898, 1891-1898. |
| APA | 张九龙.,Zhang, JL.,高增强.,Zhang, H.,Gao, ZQ.,...&董宇辉.(2014).Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein.FEBS LETTERS,588(10),1891-1898. |
| MLA | 张九龙,et al."Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein".FEBS LETTERS 588.10(2014):1891-1898. |
入库方式： OAI收割
来源：高能物理研究所
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