Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity
文献类型：期刊论文
| 作者 | Yuan Q(袁卿); Han J(韩晶); Cong WS(丛文姝) ; Yuan, Q; Han, J; Cong, WS; Ge, Y; Ma, DD; Dai, ZX; Li, YP
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| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
 |
| 出版日期 | 2014 |
| 卷号 | 9页码:4829-4846 |
| 关键词 | docetaxel docetaxel-loaded solid lipid nanoparticles breast cancer toxicity |
| 英文摘要 | Docetaxel is an adjuvant chemotherapy drug widely used to treat multiple solid tumors; however, its toxicity and side effects limit its clinical efficacy. Herein, docetaxel-loaded solid lipid nanoparticles (DSNs) were developed to reduce systemic toxicity of docetaxel while still keeping its anticancer activity. To evaluate its anticancer activity and toxicity, and to understand the molecular mechanisms of DSNs, different cellular, molecular, and whole genome transcription analysis approaches were utilized. The DSNs showed lower cytotoxicity compared with the commercial formulation of docetaxel (Taxotere(R)) and induced more apoptosis at 24 hours after treatment in vitro. DSNs can cause the treated cancer cells to arrest in the G2/M phase in a dose-dependent manner similar to Taxotere. They can also suppress tumor growth very effectively in a mice model with human xenograft breast cancer. Systemic analysis of gene expression profiles by microarray and subsequent verification experiments suggested that both DSNs and Taxotere regulate gene expression and gene function, including DNA replication, DNA damage response, cell proliferation, apoptosis, and cell cycle regulation. Some of these genes expressed differentially at the protein level although their messenger RNA expression level was similar under Taxotere and DSN treatment. Moreover, DSNs improved the main side effect of Taxotere by greatly lowering myelosuppression toxicity to bone marrow cells from mice. Taken together, these results expound the antitumor efficacy and the potential working mechanisms of DSNs in its anticancer activity and toxicity, which provide a theoretical foundation to develop and apply a more efficient docetaxel formulation to treat cancer patients. |
| 学科主题 | Science & Technology - Other Topics; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| WOS记录号 | WOS:000343168000001 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/225048]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Yuan Q,Han J,Cong WS,et al. Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2014,9:4829-4846. |
| APA | 袁卿.,韩晶.,丛文姝.,Yuan, Q.,Han, J.,...&秘晓林.(2014).Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity.INTERNATIONAL JOURNAL OF NANOMEDICINE,9,4829-4846. |
| MLA | 袁卿,et al."Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity".INTERNATIONAL JOURNAL OF NANOMEDICINE 9(2014):4829-4846. |
入库方式： OAI收割
来源：高能物理研究所
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