中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion

文献类型:期刊论文

作者Fang, GL; Zhang, DC; Yin, HL; Zheng, L; Bi, XL; Yuan, L;秘晓林
刊名JOURNAL OF CELL SCIENCE
出版日期2014
卷号127期号:8页码:1631-1639
关键词Centrosome cohesion Centlein Cep68 C-Nap1 Rootletin
英文摘要Centrosome cohesion, mostly regarded as a proteinaceous linker between parental centrioles, ensures that the interphase centrosome(s) function as a single microtubule-organizing center. Impairment of centrosome cohesion leads to the splitting of centrosomes. Although the list of cohesion proteins is growing, the precise composition and regulation of centrosome cohesion are still largely unknown. In this study, we show that the centriolar protein centlein (also known as CNTLN) localizes to the proximal ends of the centrioles and directly interacts with both C-Nap1 (also known as Cep250) and Cep68. Moreover, centlein complexes with C-Nap1 and Cep68 at the proximal ends of centrioles during interphase and functions as a molecular link between C-Nap1 and Cep68. Depletion of centlein impairs recruitment of Cep68 to the centrosomes and, in turn, results in centrosome splitting. Both centlein and Cep68 are novel Nek2A substrates. Collectively, our data demonstrate that centrosome cohesion is maintained by the newly identified complex of C-Nap1-centlein-Cep68.
学科主题Cell Biology
收录类别SCI
WOS记录号WOS:000334595500002
公开日期2016-05-03
源URL[http://ir.ihep.ac.cn/handle/311005/225070]  
专题高能物理研究所_多学科研究中心
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GB/T 7714
Fang, GL,Zhang, DC,Yin, HL,et al. Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion[J]. JOURNAL OF CELL SCIENCE,2014,127(8):1631-1639.
APA Fang, GL,Zhang, DC,Yin, HL,Zheng, L,Bi, XL,&Yuan, L;秘晓林.(2014).Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion.JOURNAL OF CELL SCIENCE,127(8),1631-1639.
MLA Fang, GL,et al."Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion".JOURNAL OF CELL SCIENCE 127.8(2014):1631-1639.

入库方式: OAI收割

来源:高能物理研究所

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