Gd@C-82(OH)(22) Nanoparticles Constrain Macrophages Migration Into Tumor Tissue to Prevent Metastasis
文献类型：期刊论文
| 作者 | Song Y(宋炎); Jin JJ(金俊江); Li J(李娟) ; Song, Y; Jin, JJ; Li, J; He, R; Zhang, MY; Chang, YA; Chen, K
|
| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 14期号:6页码:4022-4028 |
| 关键词 | Gd@C-82(OH)(22) Nanoparticles Tumor Macrophages Cell Morphology |
| 英文摘要 | Macrophages can be recruited to tumor tissues and play a supportive role in the invasion microenvironment. Since nanoparticles can be easily endocytosed by this kind of cell, the advances in nanotechnology offer a new sight to target macrophages in tumor tissues for diminishing harmful phenotypes. In the xenograft mouse model, we found that metallofullerol Gd@C-82(OH)(22) can not only reduced the macrophage density in the tumor tissue, but also decreased the expression of matrix metalloproteinase-9 produced by this kind of cell. To verify the phenomenon, a macrophage cell line, RAW264.7 was employed in the experiment, in vivo. Gd@C-82(OH)(22) nanoparticles can be engulfed by macrophages and the quantity was measured by inductively coupled plasma mass spectrometry. Fluorescent staining result showed that the particle induced the cells to adopt an elongated spindle morphology. The morphology alteration implied that the cells undergo mesenchymal migration, which is assisted by matrix metalloproteinase-9 to break down the extracellular matrix. But the reverse transcription PCR and western blots results indicated that the expression of matrix metalloproteinase-9 was reduced after the treatment of Gd@C-82(OH)(22). Thus, transwell migration assay indicated that macrophages were constrained to migrate through the collagen matrix. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000332339500003 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/225124]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Song Y,Jin JJ,Li J,et al. Gd@C-82(OH)(22) Nanoparticles Constrain Macrophages Migration Into Tumor Tissue to Prevent Metastasis[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2014,14(6):4022-4028. |
| APA | 宋炎.,金俊江.,李娟.,Song, Y.,Jin, JJ.,...&邢更妹.(2014).Gd@C-82(OH)(22) Nanoparticles Constrain Macrophages Migration Into Tumor Tissue to Prevent Metastasis.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,14(6),4022-4028. |
| MLA | 宋炎,et al."Gd@C-82(OH)(22) Nanoparticles Constrain Macrophages Migration Into Tumor Tissue to Prevent Metastasis".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 14.6(2014):4022-4028. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。