WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells
文献类型：期刊论文
| 作者 | Yong Y(雍媛); Zhou LJ(周亮君); Gu ZJ(谷战军) ; Yong, Y; Zhou, LJ; Gu, ZJ; Yan, L; Tian, G; Zheng, XP; Liu, XD
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| 刊名 | NANOSCALE
 |
| 出版日期 | 2014 |
| 卷号 | 6期号:17页码:10394-10403 |
| 英文摘要 | We have developed a simple and efficient strategy to fabricate WS2 nanosheets with low toxicity and good water solubility via a liquid exfoliation method by using H2SO4 intercalation and ultrasonication. The as-prepared WS2 nanosheets were employed not only as an NIR absorbing agent for photothermal therapy (PTT) but also as a photosensitizer (PS) carrier for photodynamic therapy (PDT) due to their sheet like structure that offers large surface area to load PS molecules. Moreover, singlet-oxygen generation of the PSs-WS2 complex could be finely controlled by NIR irradiation that could manipulate the PSs release behavior from WS2 nanosheets. The synergistic anti-tumor effect of WS2 nanosheets mediated PDT-PTT was also evaluated carefully and the results clearly showed that the efficacy of combined PDT-PTT treatment of cancer cells is significantly higher than those of PDT-only and PTT-only treatment, indicating enhanced efficiency of the combined therapeutic system. In addition, the WS2 could be used as a computed tomography (CT) contrast agent for bio-imaging since W atoms have strong X-ray attenuation ability, making them a multifunctional theranostic platform for simultaneous imaging-guided diagnosis and therapy. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000340520500063 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/225199]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Yong Y,Zhou LJ,Gu ZJ,et al. WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells[J]. NANOSCALE,2014,6(17):10394-10403. |
| APA | 雍媛.,周亮君.,谷战军.,Yong, Y.,Zhou, LJ.,...&赵宇亮.(2014).WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells.NANOSCALE,6(17),10394-10403. |
| MLA | 雍媛,et al."WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells".NANOSCALE 6.17(2014):10394-10403. |
入库方式： OAI收割
来源：高能物理研究所
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