Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma
文献类型：期刊论文
| 作者 | Li, JQ; Li, L; 陈汉清;Chen, HQ; Chang, Q; Liu, XD; Wu, Y; Wei, CX; Li, R; Kwan, JKC; Yeung, KL |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2014 |
| 卷号 | 4页码:4275 |
| 英文摘要 | The aggravating effects of zero-dimensional, particle-shaped nanomaterials on allergic asthma have been previously investigated, but similar possible effects of one-dimensional shaped nanomaterials have not been reported. More importantly, there are no available means to counteract the adverse nanomaterial effects to allow for their safe use. In this study, an ovalbumin (OVA)-sensitized rat asthma model was established to investigate whether single walled carbon nanotubes (SWCNTs) aggravate allergic asthma. The results showed that SWCNTs in rats exacerbated OVA-induced allergic asthma and that this exacerbation was counteracted by concurrent administration vitamin E. A mechanism involving the elimination of reactive oxygen species, downregulation of Th2 responses, reduced Ig production, and the relief of allergic asthma symptoms was proposed to explain the antagonistic effects of vitamin E. This work could provide a universal strategy to effectively protect people with allergic asthma from SWCNTs or similar nanomaterial-induced aggravating effects. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000332203300003 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/225365]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Li, JQ,Li, L,陈汉清；Chen, HQ,et al. Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma[J]. SCIENTIFIC REPORTS,2014,4:4275. |
| APA | Li, JQ.,Li, L.,陈汉清；Chen, HQ.,Chang, Q.,Liu, XD.,...&Yang, X.(2014).Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma.SCIENTIFIC REPORTS,4,4275. |
| MLA | Li, JQ,et al."Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma".SCIENTIFIC REPORTS 4(2014):4275. |
入库方式： OAI收割
来源：高能物理研究所
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