Integrated analytical techniques with high sensitivity for studying brain translocation and potential impairment induced by intranasally instilled copper nanoparticles
文献类型：期刊论文
| 作者 | Bai R(白茹); Zhang LL(张丽丽); Liu Y(刘颖); Bai, R; Zhang, LL; Liu, Y; Li, B; Wang, LM; Wang, P; Autrup, H |
| 刊名 | TOXICOLOGY LETTERS
 |
| 出版日期 | 2014 |
| 卷号 | 226期号:1页码:70-80 |
| 关键词 | Copper nanoparticles Brain translocation ICP-MS SRXRF Histopathological examination |
| 英文摘要 | Health impacts of inhalation exposure to engineered nanomaterials have attracted increasing attention. In this paper, integrated analytical techniques with high sensitivity were used to study the brain translocation and potential impairment induced by intranasally instilled copper nanoparticles (CuNPs). Mice were exposed to CuNPs in three doses (1, 10, 40 mg/kg bw). The body weight of mice decreased significantly in the 10 and 40 mg/kg group (p < 0.05) but recovered slightly within exposure duration. Inductively coupled plasma mass spectrometry (ICP-MS) analysis showed that CuNPs could enter the brain. Altered distribution of some important metal elements was observed by synchrotron radiation X-ray fluorescence (SRXRF). H&E staining and immunohistochemical analysis showed that CuNPs produced damages to nerve cells and astrocyte might be the one of the potential targets of CuNPs. The changes of neurotransmitter levels in different brain regions demonstrate that the dysfunction occurred in exposed groups. These data indicated that CuNPs could enter the brain after nasal inhalation and induced damages to the central nervous system (CNS). Integration of effective analytical techniques for systematic investigations is a promising direction to better understand the biological activities of nanomaterials. (C) 2014 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Toxicology |
| 收录类别 | SCI |
| WOS记录号 | WOS:000332409000010 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/225384]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Bai R,Zhang LL,Liu Y,et al. Integrated analytical techniques with high sensitivity for studying brain translocation and potential impairment induced by intranasally instilled copper nanoparticles[J]. TOXICOLOGY LETTERS,2014,226(1):70-80. |
| APA | 白茹.,张丽丽.,刘颖.,Bai, R.,Zhang, LL.,...&陈春英.(2014).Integrated analytical techniques with high sensitivity for studying brain translocation and potential impairment induced by intranasally instilled copper nanoparticles.TOXICOLOGY LETTERS,226(1),70-80. |
| MLA | 白茹,et al."Integrated analytical techniques with high sensitivity for studying brain translocation and potential impairment induced by intranasally instilled copper nanoparticles".TOXICOLOGY LETTERS 226.1(2014):70-80. |
入库方式： OAI收割
来源：高能物理研究所
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