Tyrosine phosphorylation/dephosphorylation regulates peroxynitrite-mediated peptide nitration
文献类型：期刊论文
| 作者 | Shi WQ(石伟群) ; Xu DD(徐殿斗); Shi, WQ; Cai, H; Xu, DD; Su, XY; Lei, P; Zhao, YF; Li, YM
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| 刊名 | REGULATORY PEPTIDES
 |
| 出版日期 | 2007 |
| 卷号 | 144期号:1-3页码:1-5 |
| 关键词 | tyrosine tryptophan nitration phosphorylation peroxynitrite |
| 通讯作者 | Li, YM (reprint author), Tsing Hua Univ, Dept Chem, Key Lab Bioorgan Phosphorous Chem, Beijing 100084, Peoples R China. |
| 英文摘要 | Proteins are targets of reactive nitrogen species such as peroxynitrite and nitrogen dioxide. Among the various amino acids in proteins, tyrosine and tryptophan residues are especially susceptible to attack by reactive nitrogen species. On the other hand, protein tyrosine phosphorylation has gained much attention in respect to cellular regulatory events and signal transduction. Peroxynitrite-mediated nitration of peptide YPPPPPW and phosphopeptide pYPPPPPW were studied at pH 7.4. The predominant nitrated products were separated and identified by reverse phase high performance liquid chromatography coupled with electrospray ionization mass spectrometry (LC-MS). The nitration sites were established by tandem electrospray ionization-mass spectrometry (LC-MS/MS). A regulatory effect of tyrosine phosphorylation/dephosphorylation on peptide nitration was observed. YPPPPPW was predominantly nitrated at tyrosine residue while pYPPPPPW was nitrated at tryptophan one. Our results can help in understanding the biochemical significance of the relationship of tyrosine phosphorylation and nitration in proteins. (c) 2007 Elsevier B.V All rights reserved. |
| 学科主题 | Endocrinology & Metabolism; Physiology |
| 类目[WOS] | Endocrinology & Metabolism ; Physiology |
| 收录类别 | SCI |
| WOS记录号 | WOS:000251601800001 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/225436]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Shi WQ,Xu DD,Shi, WQ,et al. Tyrosine phosphorylation/dephosphorylation regulates peroxynitrite-mediated peptide nitration[J]. REGULATORY PEPTIDES,2007,144(1-3):1-5. |
| APA | 石伟群.,徐殿斗.,Shi, WQ.,Cai, H.,Xu, DD.,...&Li, YM.(2007).Tyrosine phosphorylation/dephosphorylation regulates peroxynitrite-mediated peptide nitration.REGULATORY PEPTIDES,144(1-3),1-5. |
| MLA | 石伟群,et al."Tyrosine phosphorylation/dephosphorylation regulates peroxynitrite-mediated peptide nitration".REGULATORY PEPTIDES 144.1-3(2007):1-5. |
入库方式： OAI收割
来源：高能物理研究所
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