Interaction Between Nano-Anatase TiO2 and Liver DNA from Mice In Vivo
文献类型：期刊论文
| 作者 | Li, N; Ma, LL; Wang, J; Zheng, L; Liu, J; Duan, YM; Liu, HT; Zhao, XY; Wang, SS; Wang, H |
| 刊名 | NANOSCALE RESEARCH LETTERS
 |
| 出版日期 | 2010 |
| 卷号 | 5期号:1页码:#REF! |
| 关键词 | Nano-anatase TiO2 Mice DNA Binding information DNA cleavage |
| 通讯作者 | Hong, FS (reprint author), Soochow Univ, Coll Med, Suzhou 215123, Peoples R China. |
| 英文摘要 | Nano-TiO2 was shown to cause various toxic effects in both rats and mice; however, the molecular mechanism by which TiO2 exerts its toxicity is poorly understood. In this report, an interaction of nano-anatase TiO2 with liver DNA from ICR mice was systematically studied in vivo using ICP-MS, various spectral methods and gel electrophoresis. We found that the liver weights of the mice treated with higher amounts of nano-anatase TiO2 were significantly increased. Nano-anatase TiO2 could be accumulated in liver DNA by inserting itself into DNA base pairs or binding to DNA nucleotide that bound with three oxygen or nitrogen atoms and two phosphorous atoms of DNA with the Ti-O(N) and Ti-P bond lengths of 1.87 and 2.38 , respectively, and alter the conformation of DNA. And gel electrophoresis showed that higher dose of nano-anatase TiO2 could cause liver DNA cleavage in mice. |
| 学科主题 | Science & Technology - Other Topics; Materials Science; Physics |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 收录类别 | SCI |
| WOS记录号 | WOS:000272916400017 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/226204]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Li, N,Ma, LL,Wang, J,et al. Interaction Between Nano-Anatase TiO2 and Liver DNA from Mice In Vivo[J]. NANOSCALE RESEARCH LETTERS,2010,5(1):#REF!. |
| APA | Li, N.,Ma, LL.,Wang, J.,Zheng, L.,Liu, J.,...&谢亚宁.(2010).Interaction Between Nano-Anatase TiO2 and Liver DNA from Mice In Vivo.NANOSCALE RESEARCH LETTERS,5(1),#REF!. |
| MLA | Li, N,et al."Interaction Between Nano-Anatase TiO2 and Liver DNA from Mice In Vivo".NANOSCALE RESEARCH LETTERS 5.1(2010):#REF!. |
入库方式： OAI收割
来源：高能物理研究所
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