Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study
文献类型：期刊论文
| 作者 | Hui, JJ; Zhang, ZJ; Liu, SS; Xi, GJ; Zhang, XR; Teng, GJ; Chan, KC; Wu, EX; Nie, BB; Shan, BC |
| 刊名 | BEHAVIOURAL BRAIN RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 217期号:1页码:#REF! |
| 关键词 | Hippocampus Maternal separation Environmental enrichment Magnetic resonance imaging Magnetic resonance spectroscopy Rat |
| 通讯作者 | Zhang, ZJ (reprint author), Southeast Univ, Dept Neurol, Affiliated ZhongDa Hosp, 87 DingliaQiao Rd, Nanjing, Jiangsu, Peoples R China. |
| 英文摘要 | Exposure to early life stress results in behavioural changes, and these dysfunctions may persist throughout adulthood. In this study, we investigated whether hippocampus volume and neurochemical changes were involved in the appearance of these effects in the maternal separation (MS) animal model using the noninvasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Sprague-Dawley rats exposed to MS for 180 min from postnatal days (PND) 2-14 demonstrated decreased sucrose preference, increased immobility in the forced swimming test (FST), and impaired memory in the Morris water maze in adulthood. Environmental enrichment (EE) (PND 21-60) could ameliorate the effects of MS on sucrose preference and learning and memory but not on immobility in the FST. In addition, EE significantly increased N-acetylaspartate (NAA) of MS animals. However, we did not find an effect of MS or EE on hippocampal volume. These results indicate the involvement of hippocampal neurochemistry in the behavioural changes that result from early stressful life events and their modification by post-weaning EE. Thus changes in NAA, as a measure of neuronal integrity, appear to be a sensitive correlate of these behavioural effects. (C) 2010 Elsevier B.V. All rights reserved. |
| 学科主题 | Behavioral Sciences; Neurosciences & Neurology |
| 类目[WOS] | Behavioral Sciences ; Neurosciences |
| 收录类别 | SCI |
| WOS记录号 | WOS:000286539700018 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/226307]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Hui, JJ,Zhang, ZJ,Liu, SS,et al. Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study[J]. BEHAVIOURAL BRAIN RESEARCH,2011,217(1):#REF!. |
| APA | Hui, JJ.,Zhang, ZJ.,Liu, SS.,Xi, GJ.,Zhang, XR.,...&单保慈.(2011).Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study.BEHAVIOURAL BRAIN RESEARCH,217(1),#REF!. |
| MLA | Hui, JJ,et al."Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study".BEHAVIOURAL BRAIN RESEARCH 217.1(2011):#REF!. |
入库方式： OAI收割
来源：高能物理研究所
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