Toxicological and biological effects of nanomaterials
文献类型：期刊论文
| 作者 | Chen Z(陈真); Meng H(孟幻); Xing GM(邢更妹) ; Chen CY(陈春英); Zhao YL(赵宇亮); Chen, Z; Meng, H; Xing, GM; Chen, CY; Zhao, YL
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| 刊名 | INTERNATIONAL JOURNAL OF NANOTECHNOLOGY
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| 出版日期 | 2007 |
| 卷号 | 4期号:1-2页码:#REF! |
| 关键词 | manufactured nanomaterials nanotoxicity nanobiology anticancer efficiency nanosize and nanostructure dependent nanotoxicity |
| 通讯作者 | Zhao, YL (reprint author), Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, IHEP, Beijing 100049, Peoples R China. |
| 英文摘要 | In this paper, we summarise the most recent findings on the toxicological and biological (including both favourable and adverse) effects of some studied nanomaterials (nanotubes, fallerene, metallofullerenes, their derivatives, and metallic nanoparticles). The dose-dependent, nanosize dependent, nano-structure dependent biological activity in particular nanotoxicity are discussed. Results show that some conventional methodology for assessing the biological activities of bulk materials may not be valid for nanomaterials even though they have the same chemical composition and are in mass basis. Nevertheless, this kind of research is still in its infancy, and many knowledge gaps exist that need to be filled by further studies. On the other hand, we show some intriguing examples that the adverse biological effects of nanomaterials can be reverse-utilised in biomedical fields. For instance, it was found that the 22 nm [Gd@C-82(OH)(22)], particles at a very low dose exhibit an anticancer rate of as high as similar to 60% in mice. Dose increase of 1 x 10(-7) mol/kg results in a 26% increment of anticancer efficiency. These nanoparticles have strong capacity to improve immunity and obstruct tumour invasion towards normal muscle cells but nearly without toxicity in vivo and in vitro. The fullerene derivatives with proper chemical modifications may help realise the dream of tumour chemotherapeutics of high-efficacy and low-toxicity. |
| 学科主题 | Science & Technology - Other Topics; Materials Science |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 收录类别 | SCI |
| WOS记录号 | WOS:000245674700013 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/226731]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Chen Z,Meng H,Xing GM,et al. Toxicological and biological effects of nanomaterials[J]. INTERNATIONAL JOURNAL OF NANOTECHNOLOGY,2007,4(1-2):#REF!. |
| APA | 陈真.,孟幻.,邢更妹.,陈春英.,赵宇亮.,...&Zhao, YL.(2007).Toxicological and biological effects of nanomaterials.INTERNATIONAL JOURNAL OF NANOTECHNOLOGY,4(1-2),#REF!. |
| MLA | 陈真,et al."Toxicological and biological effects of nanomaterials".INTERNATIONAL JOURNAL OF NANOTECHNOLOGY 4.1-2(2007):#REF!. |
入库方式： OAI收割
来源：高能物理研究所
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