中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Toxicological and biological effects of nanomaterials

文献类型:期刊论文

作者Chen Z(陈真); Meng H(孟幻); Xing GM(邢更妹); Chen CY(陈春英); Zhao YL(赵宇亮); Chen, Z; Meng, H; Xing, GM; Chen, CY; Zhao, YL
刊名INTERNATIONAL JOURNAL OF NANOTECHNOLOGY
出版日期2007
卷号4期号:1-2页码:#REF!
关键词manufactured nanomaterials nanotoxicity nanobiology anticancer efficiency nanosize and nanostructure dependent nanotoxicity
通讯作者Zhao, YL (reprint author), Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, IHEP, Beijing 100049, Peoples R China.
英文摘要In this paper, we summarise the most recent findings on the toxicological and biological (including both favourable and adverse) effects of some studied nanomaterials (nanotubes, fallerene, metallofullerenes, their derivatives, and metallic nanoparticles). The dose-dependent, nanosize dependent, nano-structure dependent biological activity in particular nanotoxicity are discussed. Results show that some conventional methodology for assessing the biological activities of bulk materials may not be valid for nanomaterials even though they have the same chemical composition and are in mass basis. Nevertheless, this kind of research is still in its infancy, and many knowledge gaps exist that need to be filled by further studies. On the other hand, we show some intriguing examples that the adverse biological effects of nanomaterials can be reverse-utilised in biomedical fields. For instance, it was found that the 22 nm [Gd@C-82(OH)(22)], particles at a very low dose exhibit an anticancer rate of as high as similar to 60% in mice. Dose increase of 1 x 10(-7) mol/kg results in a 26% increment of anticancer efficiency. These nanoparticles have strong capacity to improve immunity and obstruct tumour invasion towards normal muscle cells but nearly without toxicity in vivo and in vitro. The fullerene derivatives with proper chemical modifications may help realise the dream of tumour chemotherapeutics of high-efficacy and low-toxicity.
学科主题Science & Technology - Other Topics; Materials Science
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
收录类别SCI
WOS记录号WOS:000245674700013
公开日期2016-05-03
源URL[http://ir.ihep.ac.cn/handle/311005/226731]  
专题高能物理研究所_多学科研究中心
推荐引用方式
GB/T 7714
Chen Z,Meng H,Xing GM,et al. Toxicological and biological effects of nanomaterials[J]. INTERNATIONAL JOURNAL OF NANOTECHNOLOGY,2007,4(1-2):#REF!.
APA 陈真.,孟幻.,邢更妹.,陈春英.,赵宇亮.,...&Zhao, YL.(2007).Toxicological and biological effects of nanomaterials.INTERNATIONAL JOURNAL OF NANOTECHNOLOGY,4(1-2),#REF!.
MLA 陈真,et al."Toxicological and biological effects of nanomaterials".INTERNATIONAL JOURNAL OF NANOTECHNOLOGY 4.1-2(2007):#REF!.

入库方式: OAI收割

来源:高能物理研究所

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