Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice
文献类型：期刊论文
| 作者 | Yang, ST; Wang, X; Jia, G; Gu, YQ; Wang, TC; Nie, HY; Ge, CC; Wang, HF; Liu, YF; Ge CC(葛翠翠) |
| 刊名 | TOXICOLOGY LETTERS
 |
| 出版日期 | 2008 |
| 卷号 | 181期号:3页码:#REF! |
| 关键词 | Carbon nanotubes Intravenous administration Accumulation Toxicity Oxidative stress |
| 通讯作者 | Wang, HF (reprint author), Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China. |
| 英文摘要 | The biomedical application of single-walled carbon nanotubes (SWCNTs), such as drug delivery and cancer treatment, requires a clear understanding of their fate and toxicological profile after intravenous administration. In this study, the long-term accumulation and toxicity of intravenously injected SWCNTs in the main Organs (such as liver, lung and spleen) in mice were carefully studied. Although SWCNTs stayed in mice over 3 months, they showed low toxicity to mice. The long-term accumulation of SWCNTs in the main organs was evidenced by using Raman spectroscopy and TEM technique. Statistically significant changes in organ indices and serum biochemical parameters (LDH, ALT and AST) were observed. The histological observations demonstrate that slight inflammation and inflammatory cell infiltration occurred in lung, but the serum immunological indicators (CH 50 level and TNF-alpha level) remained unchanged. No apoptosis was induced in the main organs. The decreasing glutathione (GSH) level and increasing malondialdehyde (MDA) level suggest that the toxicity of SWCNTs might be due to the oxidative stress. (C) 2008 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Toxicology |
| 类目[WOS] | Toxicology |
| 收录类别 | SCI |
| WOS记录号 | WOS:000260646100007 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/226751]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Yang, ST,Wang, X,Jia, G,et al. Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice[J]. TOXICOLOGY LETTERS,2008,181(3):#REF!. |
| APA | Yang, ST.,Wang, X.,Jia, G.,Gu, YQ.,Wang, TC.,...&葛翠翠.(2008).Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice.TOXICOLOGY LETTERS,181(3),#REF!. |
| MLA | Yang, ST,et al."Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice".TOXICOLOGY LETTERS 181.3(2008):#REF!. |
入库方式： OAI收割
来源：高能物理研究所
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