Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice
文献类型：期刊论文
| 作者 | Zhang Y(张燕); Li B(李柏) ; Chen CY(陈春英); Zhang, Y; Li, B; Chen, CY; Gao, ZH
|
| 刊名 | BIOMETALS
 |
| 出版日期 | 2009 |
| 卷号 | 22期号:2页码:#REF! |
| 关键词 | Iron overload Metalloproteins Hepatic distribution SEC-HPLC-ICP-MS |
| 通讯作者 | Chen, CY (reprint author), Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100049, Peoples R China. |
| 英文摘要 | Subcellular distribution of metal-containing proteins of Fe, Cu, Zn and Cd were determined in the liver samples of iron overload mice by size exclusion high performance liquid chromatography with on-line coupling to UV and inductively coupled plasma mass spectrometry. Collision cell techniques was used to remove polyatomic interferences for some elements, such as Fe. Comparative molecular weight (MW) information of the elemental fraction was obtained within a retention time of 40 min. Fe was present only in high-MW (HMW) protein; Cu, Zn and Cd were found in different MW proteins. It was also observed that these four elements studied showed predominant association with HMW fractions. Moreover, compared with the normal group, we found that the contents of these elements except Cu significantly increased and the distribution of some elements like Cd changed in iron overload mouse liver. It means that excessive iron accumulation in vivo may affect the metabolism of other element such as Zn and Cd. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 收录类别 | SCI |
| WOS记录号 | WOS:000264546600006 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/227197]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 推荐引用方式 GB/T 7714 | Zhang Y,Li B,Chen CY,et al. Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice[J]. BIOMETALS,2009,22(2):#REF!. |
| APA | 张燕.,李柏.,陈春英.,Zhang, Y.,Li, B.,...&Gao, ZH.(2009).Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice.BIOMETALS,22(2),#REF!. |
| MLA | 张燕,et al."Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice".BIOMETALS 22.2(2009):#REF!. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。