Using Hollow Carbon Nanospheres as a Light-Induced Free Radical Generator To Overcome Chemotherapy Resistance
文献类型：期刊论文
| 作者 | Wang LM(王黎明) ; Wang, LM; Sun, Q; Wang, X; Wen, T; Yin, JJ; Wang, PY; Bai, R; Zhang, XQ; Zhang, LH
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| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2015 |
| 卷号 | 137期号:5页码:1947-1955 |
| 英文摘要 | Under evolutionary pressure from chemotherapy, cancer cells develop resistance characteristics such as a low redox state, which eventually leads to treatment failures. An attractive option for combatting resistance is producing a high concentration of produced free radicals in situ. Here, we report the production and use of dispersible hollow carbon nanospheres (HCSs) as a novel platform for delivering the drug doxorubicine (DOX) and generating additional cellular reactive oxygen species using near-infrared laser irradiation. These irradiated HCSs catalyzed sufficiently persistent free radicals to produce a large number of heat shock factor-1 protein homotrimers, thereby suppressing the activation and function of resistance-related genes. Laser irradiation also promoted the release of DOX from lysosomal DOX@HCSs into the cytoplasm so that it could enter cell nuclei. As a result, DOX@HCSs reduced the resistance of human breast cancer cells (MCF-7/ADR) to DOX through the synergy among photothermal effects, increased generation of free radicals, and chemotherapy with the aid of laser irradiation. HCSs can provide a unique and versatile platform for combatting chemotherapy-resistant cancer cells. These findings provide new clinical strategies and insights for the treatment of resistant cancers. |
| 学科主题 | Chemistry |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 收录类别 | SCI ; EI ; CA |
| WOS记录号 | WOS:000349575800037 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228092]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Wang LM,Wang, LM,Sun, Q,et al. Using Hollow Carbon Nanospheres as a Light-Induced Free Radical Generator To Overcome Chemotherapy Resistance[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2015,137(5):1947-1955. |
| APA | 王黎明.,Wang, LM.,Sun, Q.,Wang, X.,Wen, T.,...&Chen, CY.(2015).Using Hollow Carbon Nanospheres as a Light-Induced Free Radical Generator To Overcome Chemotherapy Resistance.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,137(5),1947-1955. |
| MLA | 王黎明,et al."Using Hollow Carbon Nanospheres as a Light-Induced Free Radical Generator To Overcome Chemotherapy Resistance".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137.5(2015):1947-1955. |
入库方式： OAI收割
来源：高能物理研究所
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