Evaluation of the influence of fullerenol on aging and stress resistance using Caenorhabditis elegans
文献类型：期刊论文
| 作者 | Cong WS(丛文姝) ; Cong, WS; Wang, P; Qu, Y; Tang, JL; Bai, R; Zhao, YL; Chen, CY; Bi, XL; Zhao YL(赵宇亮)
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| 刊名 | BIOMATERIALS
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| 出版日期 | 2015 |
| 卷号 | 42页码:78-86 |
| 关键词 | Fullerenol Anti-aging Caenorhabditis elegans Lifespan DAF-16 Insulin/IGF-1 pathway |
| 通讯作者 | 秘晓林 |
| 英文摘要 | Fullerene derivatives have attracted extensive attention in biomedical fields and polyhydroxyl fullerene (fullerenol), a water-soluble fullerene derivative, is demonstrated as a powerful antioxidant. To further assess their anti-aging and anti-stress potential, we employed Caenorhabditis elegans (C elegans) as a model organism to evaluate the effects of fullerenol on the growth, development, behavior and anti-stress ability in vivo. The data show that fullerenol has no obviously toxic effect on nematodes and can delay C elegans aging progress under normal condition. Further studies demonstrate that fullerenol attenuates endogenous levels of reactive oxygen species and provides protection to C elegans under stress conditions by up-regulating stress-related genes in a DAF-16 depend manner and improving lifespan. In summary, our data suggest that fullerenol might be a safe and reasonable anti-aging candidate with great potential in vivo. (C) 2014 Elsevier Ltd. All rights reserved. |
| 学科主题 | Engineering; Materials Science |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 收录类别 | SCI ; EI ; CA |
| WOS记录号 | WOS:000348883700008 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228121]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Cong WS,Cong, WS,Wang, P,et al. Evaluation of the influence of fullerenol on aging and stress resistance using Caenorhabditis elegans[J]. BIOMATERIALS,2015,42:78-86. |
| APA | 丛文姝.,Cong, WS.,Wang, P.,Qu, Y.,Tang, JL.,...&秘晓林.(2015).Evaluation of the influence of fullerenol on aging and stress resistance using Caenorhabditis elegans.BIOMATERIALS,42,78-86. |
| MLA | 丛文姝,et al."Evaluation of the influence of fullerenol on aging and stress resistance using Caenorhabditis elegans".BIOMATERIALS 42(2015):78-86. |
入库方式： OAI收割
来源：高能物理研究所
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