Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor
文献类型：期刊论文
| 作者 | Liu Y(刘颖); Chen CY(陈春英); Sun BY(孙宝云); Wang LM(王黎明); Gao XF(高兴发); Dong JQ(董金泉); Zhao F(赵峰); Zhao YL(赵宇亮); Liu, Y; Chen, CY |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2015 |
| 卷号 | 6页码:5988 |
| 通讯作者 | 刘颖 ; 陈春英 |
| 英文摘要 | The contemporary use of nanomedicines for cancer treatment has been largely limited to serving as carriers for existing therapeutic agents. Here, we provide definitive evidence that, the metallofullerenol nanomaterial Gd@C-82(OH)(22), while essentially not toxic to normal mammary epithelial cells, possesses intrinsic inhibitory activity against triple-negative breast cancer cells. Gd@C-82(OH)(22) blocks epithelial-to-mesenchymal transition with resultant efficient elimination of breast cancer stem cells (CSCs) resulting in abrogation of tumour initiation and metastasis. In normoxic conditions, Gd@C-82(OH)(22) mediates these effects by blocking TGF-alpha signalling. Moreover, under hypoxic conditions found in the tumour micro-environment, cellular uptake of Gd@C-82(OH)(22) is facilitated where it functions as a bi-potent inhibitor of HIF-1 alpha and TGF-beta activities, enhancing CSC elimination. These studies indicate that nanomaterials can be engineered to directly target CSCs. Thus, Gd-metallofullerenol is identified as a kind of non-toxic CSC specific inhibitors with significant therapeutic potential. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 收录类别 | SCI ; CA |
| WOS记录号 | WOS:000348812100006 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228179]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Liu Y,Chen CY,Sun BY,et al. Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor[J]. NATURE COMMUNICATIONS,2015,6:5988. |
| APA | 刘颖.,陈春英.,孙宝云.,王黎明.,高兴发.,...&Zhao, YL.(2015).Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor.NATURE COMMUNICATIONS,6,5988. |
| MLA | 刘颖,et al."Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor".NATURE COMMUNICATIONS 6(2015):5988. |
入库方式： OAI收割
来源：高能物理研究所
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