Nanosurface chemistry and dose govern the bioaccumulation and toxicity of carbon nanotubes, metal nanomaterials and quantum dots in vivo
文献类型：期刊论文
| 作者 | Zhao F(赵峰) ; Yan L(晏亮); Wang B(汪冰); Zhao YL(赵宇亮); Zhao, F; Meng, H; Yan, L; Wang, B; Zhao, YL
|
| 刊名 | SCIENCE BULLETIN
 |
| 出版日期 | 2015 |
| 卷号 | 60期号:1页码:3-20 |
| 关键词 | Bioaccumulation Toxicity Targeted organs Carbon nanotubes Metal nanomaterials Quantum dots |
| 通讯作者 | 赵宇亮 |
| 英文摘要 | The chemical and biological mechanisms of life processes mostly consist of multistep and programmed processes at nanoscale levels. Interestingly enough, cell, the basic functional unit and platform that maintains life processes, is composed of various organelles fulfilling sophisticated functions through the precise control on the biomolecules (e.g., proteins, phospholipid, nucleic acid and ions) in a spatial dimension of nanoscale sizes. Thus, understanding of the activities of manufactured nanoscale materials including their interaction with biological systems is of great significance in chemistry, materials science, life science, medicine, environmental science and toxicology. In this brief review, we summarized the recent advances in nanotoxicological chemistry through the dissection of pivotal factors (primarily focusing on dose and nanosurface chemistry) in determining nanomaterial-induced biological/toxic responses with particular emphasis on the nanomaterial bioaccumulation (and interaction organs or target organs) at intact animal level. Due to the volume of manufacture and material application, we deliberately discussed carbon nanotubes, metal/metal oxide nanomaterials and quantum dots, severing as representative material types to illustrate the impact of dose and nanosurface chemistry in these toxicological scenarios. Finally, we have also delineated the grand challenges in this field in a conceptual framework of nanotoxicological chemistry. It is noted that this review is a part of our persistent endeavor of building the systematic knowledge framework for toxicological properties of engineered nanomaterials. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 收录类别 | SCI ; CA |
| WOS记录号 | WOS:000347924400003 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228198]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Zhao F,Yan L,Wang B,et al. Nanosurface chemistry and dose govern the bioaccumulation and toxicity of carbon nanotubes, metal nanomaterials and quantum dots in vivo[J]. SCIENCE BULLETIN,2015,60(1):3-20. |
| APA | 赵峰.,晏亮.,汪冰.,赵宇亮.,Zhao, F.,...&Zhao, YL.(2015).Nanosurface chemistry and dose govern the bioaccumulation and toxicity of carbon nanotubes, metal nanomaterials and quantum dots in vivo.SCIENCE BULLETIN,60(1),3-20. |
| MLA | 赵峰,et al."Nanosurface chemistry and dose govern the bioaccumulation and toxicity of carbon nanotubes, metal nanomaterials and quantum dots in vivo".SCIENCE BULLETIN 60.1(2015):3-20. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。