Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity
文献类型：期刊论文
| 作者 | Wang LM(王黎明) ; Zhang TL(张田露); Li PY(李盼云); Huang WX(黄万霞); Tang JL(唐景龙); Wang PY(王鹏阳); Liu J(刘景); Yuan QX(袁清习); Bai R(白茹); Li B(李柏)
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| 刊名 | ACS NANO
 |
| 出版日期 | 2015 |
| 卷号 | 9期号:6页码:6532-6547 |
| 关键词 | chemical origin nanotoxicity dynamic processes of intracellular nanoparticles chemical transformation AgNPs nano-CT |
| 通讯作者 | 陈春英 |
| 英文摘要 | To predict potential medical value or toxicity of nanoparticles (NPs), it is necessary to understand the chemical transformation during intracellular processes of NPs. However, it is a grand challenge to capture a high-resolution image of metallic NPs in a single cell and the chemical information on intracellular NPs. Here, by integrating synchrotron radiation-beam transmission X-ray microscopy (SR-TXM) and SR-X-ray absorption near edge structure (SR-XANES) spectroscopy, we successfully capture the 3D distribution of silver NPs (AgNPs) inside a single human monocyte (THP-1), associated with the chemical transformation of silver. The results reveal that the cytotoxicity of AgNPs is largely due to the chemical transformation of particulate silver from elemental silver (Ag-0)(n), to Ag+ ions and Ag-0-, then Ag-S- species. These results provide direct evidence in the long-lasting debate on whether the nanoscale or the ionic form dominates the cytotoxicity of silver nanoparticles. Further, the present approach provides an integrated strategy capable of exploring the chemical origins of cytotoxicity in metallic nanoparticles. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 收录类别 | SCI ; EI ; CA |
| WOS记录号 | WOS:000356988500096 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228633]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 推荐引用方式 GB/T 7714 | Wang LM,Zhang TL,Li PY,et al. Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity[J]. ACS NANO,2015,9(6):6532-6547. |
| APA | 王黎明.,张田露.,李盼云.,黄万霞.,唐景龙.,...&Chen, CY.(2015).Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity.ACS NANO,9(6),6532-6547. |
| MLA | 王黎明,et al."Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity".ACS NANO 9.6(2015):6532-6547. |
入库方式： OAI收割
来源：高能物理研究所
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