Gd-Metallofullerenol Nanomaterial Suppresses Pancreatic Cancer Metastasis by Inhibiting the Interaction of Histone Deacetylase 1 and Metastasis-Associated Protein 1
文献类型：期刊论文
| 作者 | Pan, YM; Wang, LM; Kang, SG; Lu, YY; Yang, ZX; Huynh, T; Chen, CY; Zhou, RH; Guo, MZ; Zhao, YL |
| 刊名 | ACS NANO
 |
| 出版日期 | 2015 |
| 卷号 | 9期号:7页码:6826-6836 |
| 关键词 | pancreatic cancer Gd@C-82(OH)(22) metastasis HDAC1 MTA1 HIF-1 alpha RECK |
| 通讯作者 | 赵宇亮 |
| 英文摘要 | The treatment of pancreatic cancer frequently fails due to local recurrence and hepatic metastasis. Our previous study found that Gd@C-82(OH)(22) can suppress pancreatic cancer by inhibiting MMP-2/9 expression. In this study, we further explored the epigenetic mechanism of Gd@C-82(OH)(22) in human pancreatic cancer metastasis. Gd@C-82(OH)(22) suppressed tumor metastasis through down-regulation of metastasis-associated protein 1 (MTA1), HDAC1, HIF-1 alpha, and MMP-2/9 and up-regulation of reversion-cysteine protein with the Kazal motif (RECK). The level of acetylation was increased in the promoter region of the RECK gene after Gd@C-82(OH)(22) treatment. The interaction of MTA1, HDAC1, and HIF-1 alpha was inhibited by Gd@C-82(OH)(22). Furthermore, large-scale molecular dynamics simulations revealed Gd@C-82(OH)(22) could serve as an effective HDAC inhibitor to the protein protein association between HDAC1 and MTA1, especially through MTA1's SANT and ELM2 dimerization domains. Our findings implicate Gd@C-82(OH)(22) as a novel HDAC inhibitor acting to increase RECK expression by suppressing the MTA1/HDAC1 co-repressor complex. Gd@C-82(OH)(22) may serve as a potential HDAC1 inhibitor to suppress pancreatic cancer cell invasion and metastasis both in vitro and in vivo. According to computer analysis and experimental validation, Gd@C-82(OH)(22) activates RECK expression by inhibiting the interaction of HDAC1 and MTA1. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 收录类别 | SCI ; EI |
| WOS记录号 | WOS:000358823200019 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228687]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Pan, YM,Wang, LM,Kang, SG,et al. Gd-Metallofullerenol Nanomaterial Suppresses Pancreatic Cancer Metastasis by Inhibiting the Interaction of Histone Deacetylase 1 and Metastasis-Associated Protein 1[J]. ACS NANO,2015,9(7):6826-6836. |
| APA | Pan, YM.,Wang, LM.,Kang, SG.,Lu, YY.,Yang, ZX.,...&赵宇亮.(2015).Gd-Metallofullerenol Nanomaterial Suppresses Pancreatic Cancer Metastasis by Inhibiting the Interaction of Histone Deacetylase 1 and Metastasis-Associated Protein 1.ACS NANO,9(7),6826-6836. |
| MLA | Pan, YM,et al."Gd-Metallofullerenol Nanomaterial Suppresses Pancreatic Cancer Metastasis by Inhibiting the Interaction of Histone Deacetylase 1 and Metastasis-Associated Protein 1".ACS NANO 9.7(2015):6826-6836. |
入库方式： OAI收割
来源：高能物理研究所
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