Sensitive Detection of a Modified Base in Single-Stranded DNA by a Single-Walled Carbon Nanotube
文献类型：期刊论文
| 作者 | Zhang S(张爽); Wang XF(王晓峰) ; Li T(李婷); 刘蕾(多); Wu HC(吴海臣); Li JY(李敬源); Zhang, S; Wang, XF; Li, T; Liu, L
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| 刊名 | LANGMUIR
 |
| 出版日期 | 2015 |
| 卷号 | 31期号:36页码:10094-10099 |
| 英文摘要 | In this work, we use molecular dynamics simulations to study the responses of the configuration of single-strand DNA (ssDNA) within a carbon nanotube (CNT) and the concomitant ion flow to a single modified base, i.e., benzoimidazole (Bzim)-modified 5-hydroxymethyl cytosine (5hmC). Our simulation results show the Bzim-modified 5hmC can considerably increase the ion flow through a single-walled carbon nanotube (SWCNT), despite its larger size, which is consistent with prior experimental results. This phenomenon is attributed to enhanced adsorption of DNA to the interior wall of the CNT driven by the Bzim-modified 5hmC, leading to a reduced steric effect on ion transport through the CNT. As revealed in this work, the distribution of ssDNA can be affected by limited change in the interactions with the CNT surface. Such behavior of ssDNA within small-sized CNTs can be exploited to further improve the sensitivity of nanopore detection. |
| 学科主题 | Chemistry; Materials Science |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary |
| 收录类别 | SCI ; EI |
| WOS记录号 | WOS:000361415900040 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228728]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_核技术应用研究中心 |
| 推荐引用方式 GB/T 7714 | Zhang S,Wang XF,Li T,et al. Sensitive Detection of a Modified Base in Single-Stranded DNA by a Single-Walled Carbon Nanotube[J]. LANGMUIR,2015,31(36):10094-10099. |
| APA | 张爽.,王晓峰.,李婷.,刘蕾.,吴海臣.,...&Li, JY.(2015).Sensitive Detection of a Modified Base in Single-Stranded DNA by a Single-Walled Carbon Nanotube.LANGMUIR,31(36),10094-10099. |
| MLA | 张爽,et al."Sensitive Detection of a Modified Base in Single-Stranded DNA by a Single-Walled Carbon Nanotube".LANGMUIR 31.36(2015):10094-10099. |
入库方式： OAI收割
来源：高能物理研究所
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