Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer
文献类型：期刊论文
| 作者 | Khalid, A; Wolfram, J; Ferrari, I; Mu, CF; Mai, JH; Yang, ZZ; Zhao, YL; Ferrari, M; Ma, XJ; Shen, HF |
| 刊名 | MINI-REVIEWS IN MEDICINAL CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 15期号:13页码:1063-1072 |
| 关键词 | Breast cancer CCL5 CCR5 mesenchymal stem cells metastasis triple-negative breast cancer |
| 英文摘要 | A variety of therapeutic strategies are currently under investigation to inhibit factors that promote tumor invasion, as metastasis is the most common cause of mortality for cancer patients. Notably, considerable emphasis has been placed on studying metastasis as a dynamic process that is highly dependent on the tumor microenvironment. In regards to breast cancer, chemokine C-C motif ligand 5 (CCL5), which is produced by tumor-associated stromal cells, has been established as an important contributor to metastatic disease. This review summarizes recent discoveries uncovering the role of this chemokine in breast cancer metastasis, including conditions that increase the generation of CCL5 and effects induced by this signaling pathway. In particular, CCL-5-mediated cancer cell migration and invasion are discussed in the context of intertwined feedback loops between breast cancer cells and stromal cells. Moreover, the potential use of CCL5 and its receptor chemokine C-C motif receptor 5 (CCR5) as targets for preventing breast cancer metastasis is also reviewed. |
| 学科主题 | Pharmacology & Pharmacy |
| 类目[WOS] | Chemistry, Medicinal |
| 收录类别 | SCI |
| WOS记录号 | WOS:000362116500002 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228762]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Khalid, A,Wolfram, J,Ferrari, I,et al. Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2015,15(13):1063-1072. |
| APA | Khalid, A.,Wolfram, J.,Ferrari, I.,Mu, CF.,Mai, JH.,...&赵宇亮.(2015).Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer.MINI-REVIEWS IN MEDICINAL CHEMISTRY,15(13),1063-1072. |
| MLA | Khalid, A,et al."Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer".MINI-REVIEWS IN MEDICINAL CHEMISTRY 15.13(2015):1063-1072. |
入库方式： OAI收割
来源：高能物理研究所
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