Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging
文献类型：期刊论文
| 作者 | Cao, MJ; Wang, PY; Kou, Y; Wang, J; Liu, J; Li, YH; Li, JY; Wang, LM; Chen, CY; Wang LM(王黎明)
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| 刊名 | ACS APPLIED MATERIALS & INTERFACES
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| 出版日期 | 2015 |
| 卷号 | 7期号:45页码:25014-25023 |
| 关键词 | photothermal therapy magnetic resonance imaging chemotherapy multimodal therapy drug delivery mesoporous silica nanoparticles gadolinium(III)-chelated silica nanospheres |
| 英文摘要 | The combination of therapy and diagnosis has been emerging as a promising strategy for cancer treatment. To realize chemotherapy, photothermal therapy, and magnetic resonance imaging (MRI) in one system, we have synthesized a new magnetic nanoparticle (Gd@SiO2-DOX/ICG-PDC) integrating doxorubicin (DOX), indocyanine green (ICG), and gadolinium(III)-chelated silica nanospheres (Gd@SiO2) with a poly(diallyldimethylammonium chloride) (PDC) coating. PDC coating serves as a polymer layer to protect from quick release of drugs from the nanocarriers and increase cellular uptake. The DOX release from Gd@SiO2-DOX/ICG-PDC depends on pH and temperature. The process will be accelerated in the acidic condition than in a neutral pH 7.4. Meanwhile, upon laser irradiation, the photothermal effects promote DOX release and improve the therapeutic efficacy compared to either DOX-loaded Gd@SiO2 or ICG-loaded Gd@SiO2. Moreover, MRI results show that the Gd@SiO2-PDC nanoparticles are safe T-1-type MRI contrast agents for imaging. The Gd@SiO2-PDC nanoparticles loaded with DOX and ICG can thus act as a promising theranostic platform for multimodal cancer treatment. |
| 学科主题 | Science & Technology - Other Topics; Materials Science |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 收录类别 | SCI ; EI ; CA |
| WOS记录号 | WOS:000365148600007 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228806]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Cao, MJ,Wang, PY,Kou, Y,et al. Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(45):25014-25023. |
| APA | Cao, MJ.,Wang, PY.,Kou, Y.,Wang, J.,Liu, J.,...&王黎明.(2015).Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging.ACS APPLIED MATERIALS & INTERFACES,7(45),25014-25023. |
| MLA | Cao, MJ,et al."Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging".ACS APPLIED MATERIALS & INTERFACES 7.45(2015):25014-25023. |
入库方式： OAI收割
来源：高能物理研究所
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