Evaluation and characterization of anti-estrogenic and anti-androgenic activities in soil samples along the Second Songhua River, China
文献类型：期刊论文
| ; | |
| 作者 | Li, J; Wang, YF; Kong, DD; Wang, JS; Teng, YG; Li, N; 李娜(多) |
| 刊名 | ENVIRONMENTAL MONITORING AND ASSESSMENT
 ; ENVIRONMENTAL MONITORING AND ASSESSMENT
|
| 出版日期 | 2015 ; 2015 |
| 卷号 | 187期号:11页码:724 |
| 关键词 | In vitro bioassay Estrogen receptor Androgen receptor Soil sample Endocrine-disrupting chemicals In vitro bioassay Estrogen receptor Androgen receptor Soil sample Endocrine-disrupting chemicals |
| ISSN号 | 0167-6369 |
| DOI | 10.1007/s10661-015-4933-4 |
| 文献子类 | Article |
| 英文摘要 | In the present study, re-combined estrogen receptor (ER) and androgen receptor (AR) gene yeast assays combined with a novel approach based on Monte Carlo simulation were used for evaluation and characterization of soil samples collected from Jilin along the Second Songhua River to assess their antagonist/agonist properties for ER and AR. The results showed that estrogenic activity only occurred in the soil samples collected in the agriculture area, but most soil samples showed anti-estrogenic activities, and the bioassay-derived 4-hydroxytamoxifen equivalents ranged from N.D. to 23.51 mu g/g. Hydrophilic substance fractions were determined as potential contributors associated with anti-estrogenic activity in these soil samples. Moreover, none of the soil samples exhibited AR agonistic potency, whereas 54 % of the soil samples exhibited AR antagonistic potency. The flutamide equivalents varied between N.D. and 178.05 mu g/g. Based on Monte Carlo simulation-related mass balance analysis, the AR antagonistic activities were significantly correlated with the media polar and polar fractions. All of these results support that this novel calculation method can be adopted effectively to quantify and characterize the ER/AR agonists and antagonists of the soil samples, and these data could help provide useful information for future management and remediation efforts.; In the present study, re-combined estrogen receptor (ER) and androgen receptor (AR) gene yeast assays combined with a novel approach based on Monte Carlo simulation were used for evaluation and characterization of soil samples collected from Jilin along the Second Songhua River to assess their antagonist/agonist properties for ER and AR. The results showed that estrogenic activity only occurred in the soil samples collected in the agriculture area, but most soil samples showed anti-estrogenic activities, and the bioassay-derived 4-hydroxytamoxifen equivalents ranged from N.D. to 23.51 mu g/g. Hydrophilic substance fractions were determined as potential contributors associated with anti-estrogenic activity in these soil samples. Moreover, none of the soil samples exhibited AR agonistic potency, whereas 54 % of the soil samples exhibited AR antagonistic potency. The flutamide equivalents varied between N.D. and 178.05 mu g/g. Based on Monte Carlo simulation-related mass balance analysis, the AR antagonistic activities were significantly correlated with the media polar and polar fractions. All of these results support that this novel calculation method can be adopted effectively to quantify and characterize the ER/AR agonists and antagonists of the soil samples, and these data could help provide useful information for future management and remediation efforts. |
| 学科主题 | Environmental Sciences & Ecology ; Environmental Sciences & Ecology |
| 类目[WOS] | Environmental Sciences |
| 收录类别 | SCI ; EI |
| 电子版国际标准刊号 | 1573-2959 |
| WOS研究方向 | Environmental Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000363964000066 ; WOS:000363964000066 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228830]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Li, J,Wang, YF,Kong, DD,et al. Evaluation and characterization of anti-estrogenic and anti-androgenic activities in soil samples along the Second Songhua River, China, Evaluation and characterization of anti-estrogenic and anti-androgenic activities in soil samples along the Second Songhua River, China[J]. ENVIRONMENTAL MONITORING AND ASSESSMENT, ENVIRONMENTAL MONITORING AND ASSESSMENT,2015, 2015,187, 187(11):724, 724. |
| APA | Li, J.,Wang, YF.,Kong, DD.,Wang, JS.,Teng, YG.,...&李娜.(2015).Evaluation and characterization of anti-estrogenic and anti-androgenic activities in soil samples along the Second Songhua River, China.ENVIRONMENTAL MONITORING AND ASSESSMENT,187(11),724. |
| MLA | Li, J,et al."Evaluation and characterization of anti-estrogenic and anti-androgenic activities in soil samples along the Second Songhua River, China".ENVIRONMENTAL MONITORING AND ASSESSMENT 187.11(2015):724. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。