99mTc-labeled colchicine for tumor imaging using DTPA as bifunctional chelating agent
文献类型：期刊论文
| ; | |
| 作者 | Wang JJ(汪建军); Zhang YH(张延华); Yang WJ(杨文江); Xue JQ(薛井泉); 刘宇(多); Wang, J.; Zhang, Y.; Yang, W.; Xue, J.; Liu, Y. |
| 刊名 | JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
 ; JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
|
| 出版日期 | 2016 ; 2016 |
| 卷号 | 307期号:2页码:1087-1092 |
| 关键词 | Colchicine Tc-99m-labeled Tumor imaging DTPA Bifunctional chelating agent |
| ISSN号 | 0236-5731 |
| DOI | 10.1007/s10967-015-4308-x |
| 通讯作者 | 汪建军 ; 刘宇（多） ; 汪建军 ; 刘宇（多） |
| 文献子类 | Article |
| 英文摘要 | For the purpose to develop novel 99mTc-labeled tumor imaging agents with SPECT, colchicine (CHC) was directly labeled by 99mTc using diethylene triamine pentacetate acid (DTPA) as bifunctional chelating agent. Trimethylcolchicinic acid, derivatived from colchicine, was conjugated to DTPA to get the new ligand DTPA-CHC, which was labeled by 99mTc in the presence of SnCl2 as reducing agent. The radiochem. purity of the 99mTc-DTPA-CHC complex was over 90 %. It had good hydrophilicity and was stable at room temp. The high initial tumor uptake with moderate retention, good tumor/muscle ratios and satisfactory scintigraphic images highlighted the potential of 99mTc-DTPA-CHC for tumor imaging. [on SciFinder(R)]; For the purpose to develop novel Tc-99m-labeled tumor imaging agents with SPECT, colchicine (CHC) was directly labeled by Tc-99m using diethylene triamine pentacetate acid (DTPA) as bifunctional chelating agent. Trimethylcolchicinic acid, derivatived from colchicine, was conjugated to DTPA to get the new ligand DTPA-CHC, which was labeled by Tc-99m in the presence of SnCl2 as reducing agent. The radiochemical purity of the Tc-99m-DTPA-CHC complex was over 90 %. It had good hydrophilicity and was stable at room temperature. The high initial tumor uptake with moderate retention, good tumor/muscle ratios and satisfactory scintigraphic images highlighted the potential of Tc-99m-DTPA-CHC for tumor imaging. |
| 收录类别 | CA |
| 电子版国际标准刊号 | 1588-2780 |
| 语种 | 英语 |
| WOS记录号 | WOS:000372268600027 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228868]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wang JJ,Zhang YH,Yang WJ,et al. 99mTc-labeled colchicine for tumor imaging using DTPA as bifunctional chelating agent, 99mTc-labeled colchicine for tumor imaging using DTPA as bifunctional chelating agent[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2016, 2016,307, 307(2):1087-1092, 1087-1092. |
| APA | 汪建军.,张延华.,杨文江.,薛井泉.,刘宇.,...&Liu, Y..(2016).99mTc-labeled colchicine for tumor imaging using DTPA as bifunctional chelating agent.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,307(2),1087-1092. |
| MLA | 汪建军,et al."99mTc-labeled colchicine for tumor imaging using DTPA as bifunctional chelating agent".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 307.2(2016):1087-1092. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。