Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy
文献类型：期刊论文
| 作者 | Yong Y(雍媛); Bo T(薄涛); Zu M(祖勉) ; Yan L(晏亮); Yin WY(尹文艳); Wang DL(王栋梁); Gu ZJ(谷战军); Zhao YL(赵宇亮); Yong; Y
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| 刊名 | ACS NANO
 |
| 出版日期 | 2015 |
| 卷号 | 9期号:12页码:12451-12463 |
| 关键词 | WS2 quantum dots X-ray computed tomography photoaccoustic imaging photothermal therapy radiotherapy therapy synergistic therapy |
| 通讯作者 | 谷战军 ; 赵宇亮 |
| 英文摘要 | Designing a multifunctional nanomedicine for integration of precise diagnosis and effective treatment of tumors is desirable but remains a great challenge. Here, we report a multifunctional nanomedicine based on WS2 quantum dots (QDs), which was prepared by a facile and "green" method through physical grinding and ultrasonication. The as-obtained WS2 QDs with small size (3 nm) possess not only significant X-ray computed tomography (CT)/photoaccoustic (PA) imaging signal enhancement but also remarkable photothermal therapy (PTT)/radiotherapy (RT) synergistic effect for tumor treatment. With CT/PA imaging and the synergistic effect between PTT and RT, the tumor could be accurately positioned and thoroughly eradicated in vivo after intravenous injection of WS2 QDs. Moreover, hematoxylin and eosin staining, blood hematology, and biochemistry analysis revealed no noticeable toxicity of WS2 QDs in vitro and in vivo, which confirmed that WS2 QDs possess good biocompatibility. This multifunctional nanoparticle could play an important role in facilitating simultaneously multimodal imaging and synergistic therapy between PTT and RI to achieve better therapeutic efficacy. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 收录类别 | SCI ; EI ; CA |
| WOS记录号 | WOS:000367280100098 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228881]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Yong Y,Bo T,Zu M,et al. Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy[J]. ACS NANO,2015,9(12):12451-12463. |
| APA | 雍媛.,薄涛.,祖勉.,晏亮.,尹文艳.,...&YL.(2015).Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy.ACS NANO,9(12),12451-12463. |
| MLA | 雍媛,et al."Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy".ACS NANO 9.12(2015):12451-12463. |
入库方式： OAI收割
来源：高能物理研究所
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