Molecular shape and immunogenicity of meningococcal polysaccharide group A conjugate vaccine
文献类型：期刊论文
| 作者 | Xu; M.; Xing XQ(邢雪青) ; Wu ZH(吴忠华); X. Xing; Z. Wu; Y. Du; T. Hu
|
| 刊名 | Vaccine
 |
| 出版日期 | 2015 |
| 卷号 | 33期号:43页码:5815-5821 |
| 关键词 | Neisseria meningitidis Polysaccharide Conjugate vaccine SAXS Molecular shape |
| 英文摘要 | Neisseria meningitidis is a leading cause of severe bacterial infections in infants and young children. As a major virulence factor, meningococcal capsular polysaccharide (PS) is poorly immunogenic and generally does not induce immunological memory. Conjugation of PS with a carrier protein can significantly increase the PS-specific immunogenicity and induce immunological memory. It is well known that the molecular shape/size of the conjugate vaccine is important for its immunogenicity. However, little is known about the molecular shape/size of the meningococcal conjugate vaccine. A meningococcal PS ovalbumin (OVA) conjugate vaccine was prepared using cystamine as linker. Four components (P1-P4) with different molecular size were fractionated from the conjugate. Small angle X-ray scattering (SAXS) analysis revealed that the conjugate vaccine exhibited a rod-like shape similar to virus-like particles. PS-specific immunogenicity of the conjugate vaccine was related to its molecular shape and increased as a function of its molecular size. Thus, the present study provides a three-dimensional shape of the conjugate vaccine and helps to identify optimal design of a potent meningococcal conjugate vaccine. (C) 2015 Elsevier Ltd. All rights reserved. |
| 学科主题 | Immunology; Research & Experimental Medicine |
| 类目[WOS] | Immunology ; Medicine, Research & Experimental |
| 收录类别 | SCI |
| WOS记录号 | WOS:000363824600013 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228958]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Xu,M.,Xing XQ,et al. Molecular shape and immunogenicity of meningococcal polysaccharide group A conjugate vaccine[J]. Vaccine,2015,33(43):5815-5821. |
| APA | Xu.,M..,邢雪青.,吴忠华.,X. Xing.,...&T. Hu.(2015).Molecular shape and immunogenicity of meningococcal polysaccharide group A conjugate vaccine.Vaccine,33(43),5815-5821. |
| MLA | Xu,et al."Molecular shape and immunogenicity of meningococcal polysaccharide group A conjugate vaccine".Vaccine 33.43(2015):5815-5821. |
入库方式： OAI收割
来源：高能物理研究所
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