Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release
文献类型：期刊论文
| 作者 | Huang; S; Liu; J; He; Q; Chen; HL; Cui; JB |
| 刊名 | NANO RESEARCH
 |
| 出版日期 | 2015 |
| 卷号 | 8期号:12页码:4038-4047 |
| 关键词 | copper sulfides near infrared light photothermal therapy drug release |
| 英文摘要 | Thermosensitive drug delivery systems (DDSs) face major challenges, such as remote and repeatable control of in vivo temperature, although these can increase the therapeutic efficacy of drugs. To address this issue, we coated near-infrared (NIR) photothermal Cu1.75S nanocrystals with pH/thermos-sensitive polymer by in situ polymerization. The doxorubicine (DOX) loading content was up to 40 wt.%, with less than 8.2 wt.% of DOX being leaked under normal physiological conditions (pH = 7.4, 37 A degrees C) for almost 48 h in the absence of NIR light. These nanocapsules demonstrate excellent photothermal stability by continuous longterm NIR irradiation. Based on the stable and high photothermal efficiency (55.8%), pre-loaded drugs were released as desired using 808-nm light as a trigger. Both in vitro and in vivo antitumor therapy results demonstrated that this smart nanoplatform is an effective agent for synergistic hyperthermia-based chemotherapy of cancer, demonstrating remote and noninvasive control. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 类目[WOS] | Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 收录类别 | SCI |
| WOS记录号 | WOS:000367003400028 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/229070]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Huang,S,Liu,et al. Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release[J]. NANO RESEARCH,2015,8(12):4038-4047. |
| APA | Huang.,S.,Liu.,J.,He.,...&赵宇亮.(2015).Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release.NANO RESEARCH,8(12),4038-4047. |
| MLA | Huang,et al."Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release".NANO RESEARCH 8.12(2015):4038-4047. |
入库方式： OAI收割
来源：高能物理研究所
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