Phase-contrast imaging with synchrotron hard X-ray of micro lesions of the cartilage of the femoral head in rabbits
文献类型：期刊论文
| 作者 | Sun, W; Zhang, Y; Gao, FQ; Li, ZR; Li, G; Pan, L; Li G(黎刚)
|
| 出版日期 | 2015 |
| 卷号 | 8期号:11页码:20086-20091 |
| 关键词 | Phase-contrast synchrotron femoral head cartilage |
| 英文摘要 | Background: To observe micro lesions on the cartilage of the rabbit femoral head using phase-contrast imaging with synchrotron hard X-ray and to prove that this method can be useful in the study of the degeneration of cartilage. Methods: New Zealand white rabbits were used in a micro lesion model of rabbit femoral head cartilage. Bilateral femoral heads were excised from rabbits, and micro lesions were made on one side with a specially made knife with a blade 20 mu m in width. The other femur was left intact to serve as the control. Phase-contrast imaging with synchrotron hard X-ray and conventional X-ray imaging were used to observe the cartilage. Histological changes were investigated using modified Golden tri-color staining. Results: Phase-contrast imaging with synchrotron hard X-ray clearly showed the 20 mu m lesions on the cartilage on the heads of rabbit femurs. These lesions were not visible with conventional X-ray imaging. Histological observation confirmed the presence of the microscopic lesions. Conclusion: Phase-contrast imaging with synchrotron hard X-ray can detect microscopic lesions on cartilage that cannot be detected by conventional absorption-contrast X-ray. This provides an unequivocal, non-invasive alternative to histological examination in the diagnosis of joint disease. It should be considered a new tool in osteoarthritis and cartilage research. |
| 学科主题 | Research & Experimental Medicine |
| 类目[WOS] | Medicine, Research & Experimental |
| 收录类别 | SCI |
| WOS记录号 | WOS:000371013200032 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/229273]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Sun, W,Zhang, Y,Gao, FQ,et al. Phase-contrast imaging with synchrotron hard X-ray of micro lesions of the cartilage of the femoral head in rabbits[J],2015,8(11):20086-20091. |
| APA | Sun, W.,Zhang, Y.,Gao, FQ.,Li, ZR.,Li, G.,...&黎刚.(2015).Phase-contrast imaging with synchrotron hard X-ray of micro lesions of the cartilage of the femoral head in rabbits.,8(11),20086-20091. |
| MLA | Sun, W,et al."Phase-contrast imaging with synchrotron hard X-ray of micro lesions of the cartilage of the femoral head in rabbits".8.11(2015):20086-20091. |
入库方式： OAI收割
来源：高能物理研究所
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