中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging

文献类型:期刊论文

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作者杨文江;Yang, WJ; Zhao, ZQ; Fang, W; Zhang, XZ
刊名APPLIED RADIATION AND ISOTOPES ; APPLIED RADIATION AND ISOTOPES
出版日期2013 ; 2013
卷号74页码:1-5
关键词DTPA-LSA Tc-99m ASGP Instant lyophilized kit SPECT imaging DTPA-LSA Tc-99m ASGP Instant lyophilized kit SPECT imaging
ISSN号0969-8043
DOI10.1016/j.apradiso.2012.12.009
英文摘要Diethylenetriaminepentaacetic acid neolactosyl human serum albumin (DTPA-LSA) was prepared and labeled with technetium-99m. The labeling conditions of Tc-99m-DTPA-LSA were optimized, and lyophilized kit was developed for instant preparing of Tc-99m-DTPA-LSA. Tc-99m-DTPA-LSA showed high liver uptake in normal mice (> 96% ID/g at 5 min after injection), and it could be blocked significantly by pre-injecting free neogalactosylalbumin (NGA). Single photon emission computed tomography (SPECT) study was performed in normal Japanese White rabbits and SPECT images with high quality were obtained at 15, 30, 60, and 120 min after injection of the radiotracer. The promising biological properties of Tc-99m-DTPA-LSA combined with the development of reliable and instant lyophilized DTPA-LSA kit afford the opportunity of hepatic receptor imaging for routine clinical assessment of hepatic function. (c) 2012 Elsevier Ltd. All rights reserved.; Diethylenetriaminepentaacetic acid neolactosyl human serum albumin (DTPA-LSA) was prepared and labeled with technetium-99m. The labeling conditions of Tc-99m-DTPA-LSA were optimized, and lyophilized kit was developed for instant preparing of Tc-99m-DTPA-LSA. Tc-99m-DTPA-LSA showed high liver uptake in normal mice (> 96% ID/g at 5 min after injection), and it could be blocked significantly by pre-injecting free neogalactosylalbumin (NGA). Single photon emission computed tomography (SPECT) study was performed in normal Japanese White rabbits and SPECT images with high quality were obtained at 15, 30, 60, and 120 min after injection of the radiotracer. The promising biological properties of Tc-99m-DTPA-LSA combined with the development of reliable and instant lyophilized DTPA-LSA kit afford the opportunity of hepatic receptor imaging for routine clinical assessment of hepatic function. (c) 2012 Elsevier Ltd. All rights reserved.
学科主题Chemistry; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging ; Chemistry; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging
收录类别SCI
语种英语
WOS记录号WOS:000316978400001 ; WOS:000316978400001
公开日期2016-05-03
源URL[http://ir.ihep.ac.cn/handle/311005/223754]  
专题高能物理研究所_核技术应用研究中心
推荐引用方式
GB/T 7714
杨文江;Yang, WJ,Zhao, ZQ,Fang, W,et al. The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging, The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging[J]. APPLIED RADIATION AND ISOTOPES, APPLIED RADIATION AND ISOTOPES,2013, 2013,74, 74:1-5, 1-5.
APA 杨文江;Yang, WJ,Zhao, ZQ,Fang, W,&Zhang, XZ.(2013).The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging.APPLIED RADIATION AND ISOTOPES,74,1-5.
MLA 杨文江;Yang, WJ,et al."The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging".APPLIED RADIATION AND ISOTOPES 74(2013):1-5.

入库方式: OAI收割

来源:高能物理研究所

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