The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging
文献类型：期刊论文
| ; | |
| 作者 | 杨文江;Yang, WJ; Zhao, ZQ; Fang, W; Zhang, XZ |
| 刊名 | APPLIED RADIATION AND ISOTOPES
 ; APPLIED RADIATION AND ISOTOPES
|
| 出版日期 | 2013 ; 2013 |
| 卷号 | 74页码:1-5 |
| 关键词 | DTPA-LSA Tc-99m ASGP Instant lyophilized kit SPECT imaging DTPA-LSA Tc-99m ASGP Instant lyophilized kit SPECT imaging |
| ISSN号 | 0969-8043 |
| DOI | 10.1016/j.apradiso.2012.12.009 |
| 英文摘要 | Diethylenetriaminepentaacetic acid neolactosyl human serum albumin (DTPA-LSA) was prepared and labeled with technetium-99m. The labeling conditions of Tc-99m-DTPA-LSA were optimized, and lyophilized kit was developed for instant preparing of Tc-99m-DTPA-LSA. Tc-99m-DTPA-LSA showed high liver uptake in normal mice (> 96% ID/g at 5 min after injection), and it could be blocked significantly by pre-injecting free neogalactosylalbumin (NGA). Single photon emission computed tomography (SPECT) study was performed in normal Japanese White rabbits and SPECT images with high quality were obtained at 15, 30, 60, and 120 min after injection of the radiotracer. The promising biological properties of Tc-99m-DTPA-LSA combined with the development of reliable and instant lyophilized DTPA-LSA kit afford the opportunity of hepatic receptor imaging for routine clinical assessment of hepatic function. (c) 2012 Elsevier Ltd. All rights reserved.; Diethylenetriaminepentaacetic acid neolactosyl human serum albumin (DTPA-LSA) was prepared and labeled with technetium-99m. The labeling conditions of Tc-99m-DTPA-LSA were optimized, and lyophilized kit was developed for instant preparing of Tc-99m-DTPA-LSA. Tc-99m-DTPA-LSA showed high liver uptake in normal mice (> 96% ID/g at 5 min after injection), and it could be blocked significantly by pre-injecting free neogalactosylalbumin (NGA). Single photon emission computed tomography (SPECT) study was performed in normal Japanese White rabbits and SPECT images with high quality were obtained at 15, 30, 60, and 120 min after injection of the radiotracer. The promising biological properties of Tc-99m-DTPA-LSA combined with the development of reliable and instant lyophilized DTPA-LSA kit afford the opportunity of hepatic receptor imaging for routine clinical assessment of hepatic function. (c) 2012 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging ; Chemistry; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000316978400001 ; WOS:000316978400001 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/223754]  |
| 专题 | 高能物理研究所_核技术应用研究中心 |
| 推荐引用方式 GB/T 7714 | 杨文江；Yang, WJ,Zhao, ZQ,Fang, W,et al. The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging, The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging[J]. APPLIED RADIATION AND ISOTOPES, APPLIED RADIATION AND ISOTOPES,2013, 2013,74, 74:1-5, 1-5. |
| APA | 杨文江；Yang, WJ,Zhao, ZQ,Fang, W,&Zhang, XZ.(2013).The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging.APPLIED RADIATION AND ISOTOPES,74,1-5. |
| MLA | 杨文江；Yang, WJ,et al."The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging".APPLIED RADIATION AND ISOTOPES 74(2013):1-5. |
入库方式： OAI收割
来源：高能物理研究所
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