MRI assessment of amplitude of low-frequency fluctuation in rat brains with acute cerebral ischemic stroke
文献类型：期刊论文
| 作者 | Yao, QL; Zhang, HY; Nie BB(聂彬彬) ; Nie, BB; Fang, F; Jiao, Y; Teng, GJ
|
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2012 |
| 卷号 | 509期号:1页码:22-26 |
| 关键词 | Low-frequency fluctuation Spontaneous neuronal activity Ischemic stroke fMRI |
| 英文摘要 | To investigate fluctuations in the amplitude of low-frequency blood oxygenation level-dependent (BOLD) fMRI during acute brain ischemia, and to evaluate the use of amplitude of low-frequency fluctuations (ALFFs) in resting state fMRI for assessing super-acute focal cerebral ischemic stroke. A super-acute stroke model with middle cerebral artery occlusion (MCAO) in the rat was employed. Spontaneous fluctuations were recorded using a series of gradient echo-planar imaging (EPI) images before and 30 min, 60 min, 2 h, 6 h, 12 h, and 24 h after MCAO. After preprocessing, serial fMRI data were obtained by fast Fourier transformation to calculate the ALFFs. Statistical parametric mapping software was used for the statistical analysis of ALFFs. T2-weighted images and diffusion weighted images (DWI) were also performed to detect the ischemic lesion. The signal intensities of abnormal ALFFs increased and migrated from the core of the ischemic lesion areas to the edge of lesion following MCAO. The dynamic changes in the ALFF maps demonstrated that the sizes of the ALFF regions exceeded beyond the borderline of the DWI lesions during the super-acute ischemic stroke stage. There was a significant difference in the ALFFs maps between the ischemic stroke group and the control group (P < 0.005; cluster size > 10 voxels), which mainly occurred in the periphery of the ischemic region in the cortex. These data suggest that ALFF maps provide hemodynamic BOLD information on neural activity, and have potential for predicting survival and prognosis of acute ischemic brain tissues. (C) 2011 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| WOS记录号 | WOS:000301097100006 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/223767]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Yao, QL,Zhang, HY,Nie BB,et al. MRI assessment of amplitude of low-frequency fluctuation in rat brains with acute cerebral ischemic stroke[J]. NEUROSCIENCE LETTERS,2012,509(1):22-26. |
| APA | Yao, QL.,Zhang, HY.,聂彬彬.,Nie, BB.,Fang, F.,...&Teng, GJ.(2012).MRI assessment of amplitude of low-frequency fluctuation in rat brains with acute cerebral ischemic stroke.NEUROSCIENCE LETTERS,509(1),22-26. |
| MLA | Yao, QL,et al."MRI assessment of amplitude of low-frequency fluctuation in rat brains with acute cerebral ischemic stroke".NEUROSCIENCE LETTERS 509.1(2012):22-26. |
入库方式： OAI收割
来源：高能物理研究所
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