High-frequency rTMS treatment increases white matter FA in the left middle frontal gyrus in young patients with treatment-resistant depression
文献类型：期刊论文
| 作者 | Peng, HJ; Zheng, HR; Li, LJ; Liu, JB; Zhang, Y; Shan, BC; Zhang, L; Yin, Y; Liu, J; Li, WH |
| 刊名 | JOURNAL OF AFFECTIVE DISORDERS
 |
| 出版日期 | 2012 |
| 卷号 | 136期号:3页码:249-257 |
| 关键词 | Diffusion tensor imaging (DTI) Treatment-resistant depression (TRD) Repetitive transcranial magnetic stimulation (rTMS) Fractional anisotropy (FA) |
| 英文摘要 | Background: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for treatment-resistant depression (TRD), but its therapeutic mechanisms are unclear. White matter abnormalities are thought to cause network dysfunction underlying TRD. Diffusion tensor imaging (DTI) is an ideal tool for examining neural connections and the integrity of white matter. Few studies have used DTI to investigate the impact of rTMS on alterations of whiter matter in TRD. Method: 30 young treatment-resistant unipolar depression patients (19 males and 11 females) were enrolled in a double-blind, randomized high-frequency (15 Hz) rTMS treatment study. Seventeen patients were treated with real stimulation, and 13 were treated with sham stimulation. White-matter fractional anisotropy (FA) was evaluated using voxel-based analysis (VBA) of FA maps derived from DTI before and after treatment. Twenty-five age- and gender-matched subjects were examined as a control group. Results: In an exploratory VBA method, clusters of fifty voxels or greater that survived a family-wise error (FWE)-corrected threshold of p<0.05 were considered significant. The results revealed significantly reduced FA in the left middle frontal gyrus, with peak coordinates [- 18 46 - 14] in TRD patients. This reduced FA was significantly improved after active rTMS treatment, but not sham stimulation. FA increases were correlated with decreased depressive symptoms. Limitations: This study requires replication and further clarification in a larger patient population, and optimization of stimulation locations and methods. Conclusions: These results suggest that the efficacy of rTMS on TRD is related to increased white-matter FA in the left middle frontal gyrus. (C) 2011 Elsevier B.V. All rights reserved. |
| 学科主题 | Neurosciences & Neurology; Psychiatry |
| 收录类别 | SCI |
| WOS记录号 | WOS:000301996000007 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/223909]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Peng, HJ,Zheng, HR,Li, LJ,et al. High-frequency rTMS treatment increases white matter FA in the left middle frontal gyrus in young patients with treatment-resistant depression[J]. JOURNAL OF AFFECTIVE DISORDERS,2012,136(3):249-257. |
| APA | Peng, HJ.,Zheng, HR.,Li, LJ.,Liu, JB.,Zhang, Y.,...&Zhang, ZJ；单保慈.(2012).High-frequency rTMS treatment increases white matter FA in the left middle frontal gyrus in young patients with treatment-resistant depression.JOURNAL OF AFFECTIVE DISORDERS,136(3),249-257. |
| MLA | Peng, HJ,et al."High-frequency rTMS treatment increases white matter FA in the left middle frontal gyrus in young patients with treatment-resistant depression".JOURNAL OF AFFECTIVE DISORDERS 136.3(2012):249-257. |
入库方式： OAI收割
来源：高能物理研究所
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