F-18-FDG PET Study Reveals Brain Functional Changes During Attention in Rats
文献类型：期刊论文
| 作者 | Xi, W; Su, DT; Nie BB(聂彬彬) ; Dan BC(单保慈); Nie, BB; Yu, YQ; Shan, BC; Chen, QZ; Tian, M; Zhang, H
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| 刊名 | JOURNAL OF NUCLEAR MEDICINE
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| 出版日期 | 2013 |
| 卷号 | 54期号:11页码:1969-1973 |
| 关键词 | positron emission tomography (PET) 18F-FDG neurology attention rat model |
| 英文摘要 | Attentional impairments are seen in many clinical syndromes, including attention deficit hyperactivity disorder, schizophrenia, and Alzheimer disease. Understanding the mechanism of attention can be helpful for the diagnosis and treatment of these diseases. The aim of this study was to assess brain glucose metabolic changes in a rat model of attention. Methods: Small-animal PET studies were performed at 4 stages. Statistical parametric mapping was used for image analysis. Results: Increased F-18-FDG uptake was found in the lateral hypothalamic area and left accumbens nucleus in the learning condition. Under the attentive condition, increased F-18-FDG uptake was observed in the right retrosplenial cortex but F-18-FDG uptake was decreased in the right medial geniculate nucleus. F-18-FDG uptake change in the right retrosplenial cortex was negatively correlated with correct latency of behavior performance. Conclusion: F-18-FDG small-animal PET imaging provided novel findings on attention-related glucose metabolic changes, which were significantly correlated with the behavior performance in this rat model. |
| 学科主题 | Radiology, Nuclear Medicine & Medical Imaging |
| 收录类别 | SCI |
| WOS记录号 | WOS:000326876800023 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224182]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Xi, W,Su, DT,Nie BB,et al. F-18-FDG PET Study Reveals Brain Functional Changes During Attention in Rats[J]. JOURNAL OF NUCLEAR MEDICINE,2013,54(11):1969-1973. |
| APA | Xi, W.,Su, DT.,聂彬彬.,单保慈.,Nie, BB.,...&Zhang, H.(2013).F-18-FDG PET Study Reveals Brain Functional Changes During Attention in Rats.JOURNAL OF NUCLEAR MEDICINE,54(11),1969-1973. |
| MLA | Xi, W,et al."F-18-FDG PET Study Reveals Brain Functional Changes During Attention in Rats".JOURNAL OF NUCLEAR MEDICINE 54.11(2013):1969-1973. |
入库方式： OAI收割
来源：高能物理研究所
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