Synthesis and biological evaluation of Tc-99m(CO)(3)(His-CB) as a tumor imaging agent
文献类型：期刊论文
| 作者 | Wang JJ(汪建军) ; Wang, JJ; Yang, J; Duan, XJ; Zhang, YH; Yang, WJ; Liu, Y;; Zhang YH(张延华); Yang WJ(杨文江); 刘宇(多)
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 出版日期 | 2012 |
| 卷号 | 22期号:24页码:7406-7409 |
| 关键词 | Chlorambucil [Tc-99m(CO)(3)](+) L-Histidine Tumor imaging |
| 英文摘要 | The chlorambucil L-histidine conjugate was synthesized and radiolabeled with [Tc-99m(CO)(3)](+) core to form the Tc-99m(CO)(3)(His-CB) complex. The radiochemical purity of the complex was over 90%. It had good hydrophilicity and was stable at room temperature. The high initial tumor uptake with certain retention, fast clearance from background, good tumor/non-tumor ratios and satisfactory scintigraphic images highlighted the potential of Tc-99m(CO)(3)(His-CB) as a tumor imaging agent. (C) 2012 Elsevier Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy; Chemistry |
| 收录类别 | SCI |
| WOS记录号 | WOS:000311425500023 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224297]  |
| 专题 | 高能物理研究所_核技术应用研究中心 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Wang JJ,Wang, JJ,Yang, J,et al. Synthesis and biological evaluation of Tc-99m(CO)(3)(His-CB) as a tumor imaging agent[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(24):7406-7409. |
| APA | 汪建军.,Wang, JJ.,Yang, J.,Duan, XJ.,Zhang, YH.,...&刘宇.(2012).Synthesis and biological evaluation of Tc-99m(CO)(3)(His-CB) as a tumor imaging agent.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(24),7406-7409. |
| MLA | 汪建军,et al."Synthesis and biological evaluation of Tc-99m(CO)(3)(His-CB) as a tumor imaging agent".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.24(2012):7406-7409. |
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来源：高能物理研究所
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