Brain areas involved in the acupuncture treatment of AD model rats: a PET study
文献类型：期刊论文
| 作者 | Lu, YJ; Huang, Y; Tang, CZ; Shan, BC; Cui, SY; Yang, JJ; Chen, JQ; Lin, RY; Xiao, HL; Qu, SS |
| 刊名 | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
 |
| 出版日期 | 2014 |
| 卷号 | 14页码:178 |
| 关键词 | PET Needling ST36 Rat AD |
| 英文摘要 | Background: Acupuncture may effectively treat certain symptoms of Alzheimer's disease (AD). Although several studies have used functional brain imaging to investigate the mechanisms of acupuncture treatment on AD, these mechanisms are still poorly understood. We therefore further explored the mechanism by which needling at ST36 may have a therapeutic effect in a rat AD model. Methods: A total of 80 healthy Wistar rats were divided into healthy control (n = 15) and pre-model (n = 65) groups. After inducing AD-like disease, a total of 45 AD model rats were randomly divided into three groups: the model group (n = 15), the sham-point group (n = 15), and the ST36 group (n = 15). The above three groups underwent PET scanning. PET images were processed with SPM2. Results: The brain areas that were activated in the sham-point group relative to the model group were primarily centred on the bilateral limbic system, the right frontal lobe, and the striatum, whereas the activated areas in the ST36 group were primarily centred on the bilateral limbic system (pyriform cortex), the bilateral temporal lobe (olfactory cortex), the right amygdala and the right hippocampus. Compared with the sham-point group, the ST36 group showed greater activation in the bilateral amygdalae and the left temporal lobe. Conclusion: We concluded that needling at a sham point or ST36 can increase blood perfusion and glycol metabolism in certain brain areas, and thus may have a positive influence on the cognition of AD patients. |
| 学科主题 | Integrative & Complementary Medicine |
| 收录类别 | SCI |
| WOS记录号 | WOS:000339208500001 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224867]  |
| 专题 | 高能物理研究所_核技术应用研究中心 |
| 推荐引用方式 GB/T 7714 | Lu, YJ,Huang, Y,Tang, CZ,et al. Brain areas involved in the acupuncture treatment of AD model rats: a PET study[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,14:178. |
| APA | Lu, YJ.,Huang, Y.,Tang, CZ.,Shan, BC.,Cui, SY.,...&Lai, XS；单保慈.(2014).Brain areas involved in the acupuncture treatment of AD model rats: a PET study.BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,14,178. |
| MLA | Lu, YJ,et al."Brain areas involved in the acupuncture treatment of AD model rats: a PET study".BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 14(2014):178. |
入库方式： OAI收割
来源：高能物理研究所
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