Asialoglycoprotein Receptor-Targeted Radiopharmaceuticals for Measurement of Liver Function
文献类型：期刊论文
| 作者 | Yang WJ(杨文江); 刘宇(多);Yang, W; Zhang, X; Liu, Y |
| 刊名 | CURRENT MEDICINAL CHEMISTRY
 |
| 出版日期 | 2014 |
| 卷号 | 21期号:SI1页码:4-23 |
| 关键词 | ASGP receptors hepatic imaging liver function PET radiopharmaceutical SPECT |
| 英文摘要 | The number of Asialoglycoprotein (ASGP) receptors on the hepatocytes of patients with liver disease is reduced and is thus considered a good indicator for the evaluation of liver function. ASGP receptor-targeted radiopharmaceuticals permit a non-invasive way to evaluate total and regional hepatic function and hepatic functional reserve visually and quantitatively. Over the past three decades, a variety of ASGP receptor-targeted probes have been developed with different molecular backbones (albumin, polymer, small-molecular-weight ligand), different glycol-residues (galactose, lactose, N-acetyl-galactosamine) and different chelating systems suitable for radiolabeling with SPECT isotopes (Tc-99m, In-111, Ga-67, (131)/I-125, Sm-153) and PET isotopes (Ga-68, F-18). In this review, we present an overview of ASGP receptor-targeted radiopharmaceuticals, discuss their chemistry, biodistribution, catabolism and challenge as well as application for measurement of liver function. |
| 学科主题 | Biochemistry & Molecular Biology; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| WOS记录号 | WOS:000327778900003 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224986]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Yang WJ,Liu Y,Zhang, X,et al. Asialoglycoprotein Receptor-Targeted Radiopharmaceuticals for Measurement of Liver Function[J]. CURRENT MEDICINAL CHEMISTRY,2014,21(SI1):4-23. |
| APA | 杨文江,刘宇,Zhang, X,&Liu, Y.(2014).Asialoglycoprotein Receptor-Targeted Radiopharmaceuticals for Measurement of Liver Function.CURRENT MEDICINAL CHEMISTRY,21(SI1),4-23. |
| MLA | 杨文江,et al."Asialoglycoprotein Receptor-Targeted Radiopharmaceuticals for Measurement of Liver Function".CURRENT MEDICINAL CHEMISTRY 21.SI1(2014):4-23. |
入库方式： OAI收割
来源：高能物理研究所
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