Effective connectivity of the posterior cingulate and medial prefrontal cortices relates to working memory impairment in schizophrenic and bipolar patients
文献类型：期刊论文
| 作者 | Wu, GW; Wang YX(王云霞); Wang, YX; Mwansisya, TE; Pu, WD; Zhang, HR; Liu, C; Yang, Q; Chen, EYH; Xue, ZM |
| 刊名 | SCHIZOPHRENIA RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 158期号:1-3页码:85-90 |
| 关键词 | Schizophrenia Bipolar disorder Cognition Dynamic causal modeling Effective connectivity |
| 英文摘要 | Background: Schizophrenia (SZ) and bipolar I disorder (BD) share many overlapping clinical features, confounding the current diagnostic systems. Recent studies suggest the posterior cingulate (PCC) and medial prefrontal (MPFC) cortices that are involved in SZ and BD pathophysiology. However, the roles of PCC and MPFC in providing specific distinctive and shared neural substrates between these two disorders remain largely unknown. Examining the neurophysiologic mechanism of these diseases may help explain the clinical observations and differentiate the two disorders. Methods: We used the Dynamic Casual Modeling (DCM), which is capable of eliciting hidden neuronal dynamics and reveal cross-regulation of multiple neuronal systems, to characterize the pattern of disrupted effective connectivity in the left PCC-MPFC circuit during working memory tasks in 36 SZ and 20 BD patients as well as 29 healthy controls. Results: Compared to the healthy controls, both SZ and BD patient groups exhibited significant negative effective connectivity from the left MPFC to PCC. The negative effective connectivity was more remarkable in schizophrenic patients. Only patients with BD differed from healthy controls with positive effective connectivity from the left PCC to MPFC. Conclusions: Whole brain analysis revealed deactivation of the left PCC and MPFC across all patient groups. This study provides new insight that changes in effective connectivity of the left MPFC to left PCC circuit during working memory processing may be a core pathophysiological feature distinguishing SZ from BD. (C) 2014 Elsevier B.V. All rights reserved. |
| 学科主题 | Psychiatry |
| 收录类别 | SCI |
| WOS记录号 | WOS:000341314800015 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/225356]  |
| 专题 | 高能物理研究所_核技术应用研究中心 |
| 推荐引用方式 GB/T 7714 | Wu, GW,Wang YX,Wang, YX,et al. Effective connectivity of the posterior cingulate and medial prefrontal cortices relates to working memory impairment in schizophrenic and bipolar patients[J]. SCHIZOPHRENIA RESEARCH,2014,158(1-3):85-90. |
| APA | Wu, GW.,王云霞.,Wang, YX.,Mwansisya, TE.,Pu, WD.,...&单保慈.(2014).Effective connectivity of the posterior cingulate and medial prefrontal cortices relates to working memory impairment in schizophrenic and bipolar patients.SCHIZOPHRENIA RESEARCH,158(1-3),85-90. |
| MLA | Wu, GW,et al."Effective connectivity of the posterior cingulate and medial prefrontal cortices relates to working memory impairment in schizophrenic and bipolar patients".SCHIZOPHRENIA RESEARCH 158.1-3(2014):85-90. |
入库方式： OAI收割
来源：高能物理研究所
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