Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia
文献类型：期刊论文
| 作者 | Song, TB; Nie BB(聂彬彬) ; Nie, BB; Ma, ES; Che, J; Sun, SL; Wang, YL; Shan, BC; Liu, YW; Luo, SL
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| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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| 出版日期 | 2015 |
| 卷号 | 460期号:3页码:678-683 |
| 关键词 | Schizophrenia Rat Granger causality model Connectivity fMRI |
| 英文摘要 | Schizophrenia is characterized by the disorder of "social brain". However, the alternation of connectivity density in brain areas of schizophrenia patients remains largely unknown. In this study, we successfully created a rat model of schizophrenia by the transfection of EGR3 gene into rat brain. We then investigated the connectivity density of schizophrenia susceptible regions in rat brain using functional magnetic resonance imaging (fMRI) in combination with multivariate Granger causality (GC) model. We found that the average signal strength in prefrontal lobe and hippocampus of schizophrenia model group was significantly higher than the control group. Bidirectional Granger causality connection was observed between hippocampus and thalamic in schizophrenia model group. Both connectivity density and Granger causality connection were changed in prefrontal lobe, hippocampus and thalamus after risperidone treatment. Our results indicated that fMRI in combination with GC connection analysis may be used as an important method in diagnosis of schizophrenia and evaluation the effect of antipsychotic treatment. These findings support the connectivity disorder hypothesis of schizophrenia and increase our understanding of the neural mechanisms of schizophrenia. (C) 2015 The Authors. Published by Elsevier Inc. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000359885300031 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/228658]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Song, TB,Nie BB,Nie, BB,et al. Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,460(3):678-683. |
| APA | Song, TB.,聂彬彬.,Nie, BB.,Ma, ES.,Che, J.,...&单保慈.(2015).Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,460(3),678-683. |
| MLA | Song, TB,et al."Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 460.3(2015):678-683. |
入库方式： OAI收割
来源：高能物理研究所
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