Quantitative assessment of cerebral gray matter density change in progressive supranuclear palsy using voxel based morphometry analysis and cerebral MR T1-weighted FLAIR imaging
文献类型：期刊论文
| 作者 | Wang; GH; Wang; JJ; Zhan; J; Nie; BB; Li; PL |
| 刊名 | JOURNAL OF THE NEUROLOGICAL SCIENCES
 |
| 出版日期 | 2015 |
| 卷号 | 359期号:1-2页码:367-372 |
| 关键词 | PSP VBM Gray matter atrophy MRI T1-weighted FLAIR imaging Quantitative assessment |
| 通讯作者 | 单保慈 |
| 英文摘要 | Purpose: To investigate the gray matter (GM) atrophy in Progressive supranuclear palsy (PSP) using T1-weighted Fluid-Attenuated Inversion Recovery (FLAIR) images based on voxel based morphometry (VBM) method. Materials and methods: In this study, we firstly modified the conventional VBM method to make it can process the T1-weighted HAIR brain images. Then, we used this method on the 24 PSP patients and 23 healthy age- and sex-matched control subjects to find the local gray matter density changes of PSP patients. Results: Compared with healthy controls, GM reductions of PSP patients mainly located in the thalamus, basal ganglia, pons, midbrain, insular cortex, frontal cortex, temporal lobe, cerebellum, cingulate cortex and hippocampus. Conclusion: We used the modified VBM technique into T1 FLAIR data to study the brain gray matter atrophy in PSP, and found some new atrophy areas, including pallidum, middle and posterior cingulum, lingual, fusiform gyrus and the post part of inferior temporal gyrus. These areas have not been described in the former VBM studies, but they revealed abnormity in the pathologic and other studies on PSP. Our results might be expected to provide significant underlining neurology information and diagnostic value for PSP. (C) 2015 Elsevier B.V. All tights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Clinical Neurology ; Neurosciences |
| 收录类别 | SCI |
| WOS记录号 | WOS:000367276200069 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/229066]  |
| 专题 | 高能物理研究所_核技术应用研究中心 |
| 推荐引用方式 GB/T 7714 | Wang,GH,Wang,et al. Quantitative assessment of cerebral gray matter density change in progressive supranuclear palsy using voxel based morphometry analysis and cerebral MR T1-weighted FLAIR imaging[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES,2015,359(1-2):367-372. |
| APA | Wang.,GH.,Wang.,JJ.,Zhan.,...&单保慈.(2015).Quantitative assessment of cerebral gray matter density change in progressive supranuclear palsy using voxel based morphometry analysis and cerebral MR T1-weighted FLAIR imaging.JOURNAL OF THE NEUROLOGICAL SCIENCES,359(1-2),367-372. |
| MLA | Wang,et al."Quantitative assessment of cerebral gray matter density change in progressive supranuclear palsy using voxel based morphometry analysis and cerebral MR T1-weighted FLAIR imaging".JOURNAL OF THE NEUROLOGICAL SCIENCES 359.1-2(2015):367-372. |
入库方式： OAI收割
来源：高能物理研究所
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